Project Grant 2603176
- This National Science Foundation (NSF) Engineering Program (CFDA 47.041) Project Grant awarded $479,855 to Trustees of Dartmouth College to conduct research aimed at expanding the substrate range of the cellulolytic microbe Clostridium thermocellum. The goal is to improve understanding of C. thermocellum's metabolism and identify factors limiting its ability to deconstruct lignocellulosic biomass, a major renewable feedstock for biofuels and bioproducts. The project involves characterizing...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $414,451 Project Grant to the University of Wisconsin-Madison on October 1, 2026, through the Biological Sciences program (CFDA 47.074) to support collaborative research on microbial ethanol inhibition mechanisms in Clostridium thermocellum. The three-year project, scheduled for completion by September 30, 2029, will investigate whether metabolic disruptions within microbial...
- Federal Project Grant Award Summary Dartmouth College received a $517,732 Project Grant from the National Science Foundation (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences program (CFDA 47.049), awarded September 15, 2025, with completion targeted for August 31, 2028. The award supports a collaborative research initiative between a mathematician and a microbiologist to develop predictive computational models linking single-cell gene expression and growth...
- Federal Project Grant Award Summary The National Science Foundation (NSF) awarded Dartmouth College $850,435 under the Biological Sciences program (CFDA 47.074) for collaborative research addressing plant organ development through genome-wide characterization of evolutionarily conserved signaling modules. The five-year project, which commenced June 1, 2025 and concludes May 31, 2030, investigates how sulfated peptides and their receptor-like kinase interactions orchestrate plant organ formation....
- Federal Grant Award Summary Dartmouth College received a $125,888 Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041), effective July 1, 2025 through June 30, 2027. This collaborative research initiative supports the development of photonic-integrated-circuit two-photon (PIC-2P) microscopy technology designed to advance deep-tissue imaging capabilities. The primary...
- Federal Project Grant Award Summary Dartmouth College received a $690,177 Project Grant from the National Science Foundation (NSF), Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), awarded May 1, 2026, with completion targeted for April 30, 2030. This collaborative research project will deliver fundamental research outputs investigating how cells measure their nuclear-to-cytoplasmic (N/C) ratio to control the timing of zygotic genome activation...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Behavioral and Cognitive Sciences awarded Dartmouth College $172,641 under the Social, Behavioral, and Economic Sciences program (CFDA 47.075) for a two-year project grant running from September 1, 2025 through August 31, 2027. This research initiative investigates intensive agricultural development in northern environments, challenging conventional theories about the environmental and social conditions required for...
- The National Science Foundation awarded Dartmouth College $520,267 under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) from July 1, 2023 to June 30, 2026. Dartmouth will conduct research on hydrazone-based feedback loops to study how molecular switches can communicate and be used to control ensembles of molecules. This work aims to further fundamental understanding of engineering reaction cascades and self-assembling systems that can autonomously regulate catalysis...
- Federal Grant Award Summary The National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences (CFDA 47.049) program, awarded $320,000 to Dartmouth College (with collaborative participation from the University of New Hampshire) for a three-year project beginning September 1, 2025, and concluding August 31, 2028. This collaborative research initiative, led by Dr. Esteban A. Orellana Vinueza at Dartmouth College and Dr. Harish Vashisth at the University of New...
- Federal Project Grant Award Summary Dartmouth College, through its Office of Sponsored Projects, received a $660,389 Project Grant from the National Science Foundation's Division of Electrical, Communications and Cyber Systems under the Engineering program (CFDA 47.041), effective October 1, 2025, through September 30, 2028. The award supports the design, synthesis, and development of plasmonic metal-insulator-metal (MIM) nanosensors for liquid-phase sensing applications using surface-enhanced...
The National Science Foundation (NSF) awarded Dartmouth College $748,252 through the Biological Sciences program (CFDA 47.074) to support collaborative research on the mechanisms of microbial ethanol inhibition in Clostridium thermocellum. The three-year project, which commenced October 1, 2026 and will conclude September 30, 2029, investigates how ethanol toxicity affects cellulolytic thermophilic bacteria capable of converting plant material directly into biofuel. Rather than assuming alcohol toxicity operates primarily through cell membrane disruption, the research will test whether intracellular metabolic disruptions represent the primary inhibition mechanism at industrially relevant ethanol concentrations. This fundamental research addresses a critical barrier to transitioning bioethanol production from starch and sugar feedstocks to more sustainable cellulosic feedstocks derived from agricultural waste and wood. The award supports collaborative research conducted across multiple institutions, including the University of Wisconsin-Madison and partner institutions in New Hampshire. Deliverables include peer-reviewed research findings, mechanisms-based insights into ethanol inhibition pathways, and engineering principles applicable to developing alcohol-tolerant microbial strains for enhanced biofuel production efficiency. Additionally, the project provides interdisciplinary research and training opportunities for graduate and undergraduate students across collaborating institutions and engages the public through outreach programming connecting biofuel research with the local brewing and distilling community. This award aligns with NSF priorities in biotechnology, advanced materials, and manufacturing.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $748.3k | 6/25/26 |