Project Grant 2602737
- Federal Project Grant Award Summary The National Science Foundation (NSF) awarded $1.5M to the Van Andel Research Institute under the Biological Sciences program (CFDA 47.074) to support fundamental research on epigenetic regulation and gene expression control. The four-year project, initiated July 1, 2026 and concluding June 30, 2030, will investigate how asymmetric histone and DNA modifications within individual nucleosomes coordinate to regulate developmental gene expression and cell type...
- Federal Project Grant Award Summary MIT received $1,041,774 in funding from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) for a collaborative research project running from August 1, 2025, through July 31, 2029. This project grant supports fundamental research investigating analog information storage in chromatin states, with the goal of understanding how cells encode and maintain their identity through...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded $1.3 million to the University of Pennsylvania under the Biological Sciences program (CFDA 47.074) for the project "Dissecting the HIRA/HIR Chaperone Complex in the Chromatin Landscape." The award, effective July 1, 2026 through June 30, 2029, funds fundamental research into the structural and biochemical mechanisms of the HIRA/HIR (histone regulatory A/histone...
- Federal Project Grant Award Summary The National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) awarded $346,497 to the University of Michigan (Regents of the University of Michigan) on July 15, 2026, for a collaborative U.S.-United Kingdom research initiative focused on engineering novel protein-based synthetic cells. The project, which operates through June 30, 2029, will develop programmable, cell-sized protein structures derived from bacterial carboxysome building...
- Federal Project Grant Award Summary Michigan State University received $325,937 in funding from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) for a collaborative research project running from September 1, 2025, through August 31, 2028. The award supports fundamental research investigating the structural and metabolic dynamics of bacterial microcompartments (BMCs)—protein-bounded cellular compartments found...
- Federal Grant Award Summary Michigan State University received a $633,240 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074), effective August 1, 2025, through July 31, 2029. This award supports the development of novel 1H-detected solid-state nuclear magnetic resonance (NMR) methodologies to characterize complex carbohydrate biopolymers in their native cellular environments. The research...
- Federal Grant Award Summary The University of California, San Diego received a $375,000 Project Grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The four-year award, active from August 1, 2025 through July 31, 2029, supports collaborative research investigating analog information storage in chromatin states—specifically how cells maintain identity information through gene expression regulation...
- Federal Project Grant Award Summary The University of Michigan received a $449,996 Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041) effective July 1, 2026 through June 30, 2029. The award funds research to understand the role of nuclear speckles in muscle stem cells through combined application of cellular engineering, biomaterials, bioinformatics, and genomic assays. The research will investigate...
- Federal Project Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded $862,279 to the University of Michigan (Regents of the University of Michigan) under the Biological Sciences program (CFDA 47.074) to support research on RNA-RNA interactions regulating virulence gene expression in Listeria monocytogenes. The three-year project, initiated June 1, 2026 and completing May 31, 2029, will investigate how two noncoding RNAs in this...
- Federal Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded UC Berkeley $87,250 under the Biological Sciences program (CFDA 47.074) beginning September 1, 2025, with completion by August 31, 2027. This Project Grant supports the development of genomic language models (GLMs) to predict optimal fungal genomes for enhanced commercial protein production. The primary deliverables include a hierarchical genome-to-phenotype model (G2PM) for...
The National Science Foundation's Division of Molecular and Cellular Biosciences awarded $427,615 to the Regents of the University of Michigan (effective August 1, 2026, through July 31, 2029) under the Biological Sciences program (CFDA 47.074) to support collaborative research on epigenetic silencing mechanisms. The primary deliverable is fundamental scientific research investigating how intrinsically disordered regions (IDRs) of proteins regulate the recruitment and retention of histone H3 lysine 9 methylation (H3K9ME)-binding proteins in establishing stable gene expression states within living cells. Using fission yeast (Schizosaccharomyces pombe) as a model system, the research decodes the chemical properties and functional roles of IDRs in protein-DNA interactions within crowded cellular environments, thereby generating foundational knowledge applicable to biotechnology applications in synthetic protein engineering and targeted gene regulation. Beyond the core research deliverables, the award supports an interdisciplinary educational and outreach framework spanning biochemistry, physical chemistry, and biology. Tangible educational products include collaborative hands-on demonstrations and interactive classroom lectures for middle school students, direct laboratory research mentorship for undergraduate students, and postgraduate training in systems-level approaches to epigenetic regulation. This combination of basic research outputs and educational programming reflects the NSF Biological Sciences program's mission to advance scientific understanding while strengthening the Nation's scientific workforce.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 7/15/26 |