Project Grant 2548648
- Federal Project Grant Award Summary Baylor College of Medicine received a $184,151 Project Grant award dated August 15, 2026, from the National Science Foundation's Division of Biological Infrastructure under the Biological Sciences program (CFDA 47.074). The award supports collaborative research addressing a critical technical challenge in cryogenic electron microscopy (cryo-EM): preferred specimen orientation. The research will deliver theoretical and experimental tools to characterize and...
- Federal Grant Award Summary The Salk Institute for Biological Studies received a $220,000 Project Grant from the National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded June 1, 2025, with a completion date of May 31, 2028. This collaborative research initiative will develop advanced microcoaxial electro-optical mechanically flexible probes for minimally invasive interfacing with spinal neural circuits. The project will produce dual-modality probes with a footprint smaller...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Mathematical Sciences awarded a $250,000 Project Grant to the University of California, Davis, effective September 1, 2025, through August 31, 2028, under the Mathematical and Physical Sciences program (CFDA 47.049). This project will develop fast and robust algorithms to accelerate three-dimensional (3D) molecular structure reconstruction from cryo-electron microscopy (cryo-EM) imaging data. The deliverables include...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Biological Infrastructure awarded $1.2 million to the University of California, San Diego under the Biological Sciences program (CFDA 47.074) to develop advanced computational tools for peptide sequencing analysis. Initiated November 1, 2025, and extending through October 31, 2029, this Project Grant funds the creation of novel algorithms and software designed to overcome current limitations in mass...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Biological Infrastructure awarded $360,000 to the University of Colorado on August 15, 2026, under the Biological Sciences program (CFDA 47.074) to develop DeepSpiral, an innovative two-photon super-resolution microscopy technique. This collaborative research project, scheduled for completion by July 31, 2029, will integrate multiphoton and single-molecule localization microscopies to enable cellular imaging at...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Chemistry awarded a Project Grant of $602,976 to Scripps Research Institute under the Mathematical and Physical Sciences program (CFDA 47.049) effective September 1, 2025, through August 31, 2028. Under the direction of Professor Donna G. Blackmond, the research initiative explores the emergence of homochiral biological polymers from chiral molecular building blocks, investigating how exclusively one mirror-image...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded The Trustees of Columbia University in the City of New York a $1,200,000 Project Grant on March 15, 2025 to develop and apply a method of time-resolved cryo-electron microscopy (cryo-EM) to diverse biological molecules of medical importance. The project aims to use newly designed PDMS-based microfluidic chips to apply the time-resolved cryo-EM sample preparation technique, which has been...
- Federal Project Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $800,000 Project Grant to the University of California, San Diego on June 15, 2026, for collaborative research on transcriptome-wide visualization and functional characterization of RNA tertiary structures in human cells. Under this award, funded through the Biological Sciences program (CFDA 47.074) with a completion date of May 31, 2029, the research team will...
- Federal Project Grant Award Summary The Salk Institute for Biological Studies received a $1.2 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) awarded July 15, 2025, with a completion date of July 14, 2026. The award funds the acquisition and deployment of a Thermo Fisher Scientific Orbitrap IQ-X Tribrid mass spectrometer equipped with an Ultrahigh Performance Liquid Chromatography...
- Federal Project Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded $967,237 to the University of California, Santa Barbara on June 15, 2026, under the Biological Sciences program (CFDA 47.074) to investigate the mesoscale biophysics of Arginine-Glycine-Glycine (RGG)/RNA interactions. This four-year project, extending through May 31, 2030, will deliver fundamental research establishing quantitative physical principles governing how RGG...
The National Science Foundation's Division of Biological Infrastructure awarded $808,664 on August 15, 2026, to The Salk Institute for Biological Studies under the Biological Sciences program (CFDA 47.074) for collaborative research titled "Tools for Tackling Preferred Specimen Orientation in Cryo-EM." This Project Grant, which will conclude on July 31, 2029, supports fundamental research to develop theoretical and experimental tools that characterize and correct the effects of preferred specimen orientation in cryogenic electron microscopy (cryo-EM). The project addresses a critical technical barrier wherein biological protein specimens frequently adopt limited orientations within vitrified ice on specialized grids, resulting in biased or incomplete structural data that compromises map quality and validation. The deliverables include both mathematical frameworks and experimental methodologies designed to improve high-resolution protein structure determination through cryo-EM. By establishing foundations to understand and mitigate preferred orientation effects, this research will enhance structural interpretation accuracy and expand the accessibility and utility of cryo-EM for protein structure discovery nationally and internationally. The grant explicitly supports broader impact objectives spanning Science, Technology, Engineering, and Mathematics (STEM) education, public engagement, workforce competitiveness, and infrastructure development. The work will be conducted at Salk Institute's La Jolla, California facility.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $808.7k | 7/10/26 |