Project Grant 2540435
- Federal Project Grant Award Summary The University of Delaware received a $300,000 Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (Engineering program, CFDA 47.041) effective September 1, 2025, through August 31, 2027, to develop synthetic biology tools for controlling macrophage immune cell phenotype through histone lactylation modulation. The primary deliverables include precision engineering tools—lactylation...
- Federal Grant Award Summary The University of Delaware received a $500,000 Project Grant from the National Science Foundation's Division of Biological Infrastructure under the Biological Sciences program (CFDA 47.074), effective August 1, 2026 through July 31, 2029. This collaborative research award supports the development of innovative biotechnology tools for targeted proximity labeling of extracellular vesicles (EVs)—membrane-bound particles released by cellular organisms that carry...
- The National Science Foundation (NSF) has awarded a $1,000,000 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of Delaware. The objective of this 3-year grant, which runs from August 2024 to July 2027, is to develop a new strategy for real-time metabolite sensing and metabolon formation using biomolecular condensates. The research aims to create synthetic ligand-responsive transcription factor-based protein devices that can translate metabolite-induced DNA...
- Federal Project Grant Award Summary The University of Delaware received a $2.57 million Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2025, through February 28, 2030. This five-year Phase I Center of Biomedical Research Excellence (COBRE) grant funds the establishment of the Center for Biomedical Research Excellence in Multiscale Biomolecular Sensing (MBS), which...
- Federal Grant Award Summary The University of Delaware received a $279,964 Project Grant from the National Science Foundation (NSF) Directorate for Engineering (CFDA 47.041) effective September 1, 2026 through August 31, 2029. This collaborative research award supports the development of predictive computational models that characterize how the mechanical properties of soft nanoparticles interact with cell membrane mechanics to determine cellular uptake pathways. The primary deliverable is a...
- Federal Grant Award Summary The University of Delaware received a $2.4 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 1, 2025, with a completion date of May 31, 2030. This Phase III Center of Biomedical Research Excellence (COBRE) award supports the continued discovery and development of chemical probes and lead molecules for biological research and therapeutic...
- Federal Project Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded the University of Delaware a $1.45 million Project Grant (CFDA 47.074 – Biological Sciences program) effective September 1, 2026, through August 31, 2029, to investigate post-transcriptional regulation of cell division during early embryonic development. The research focuses on how microRNA-1 (mir-1) regulates mitosis and chromosomal segregation using sea urchin embryos...
- Federal Grant Award Summary The University of Delaware received a $876,000 Project Grant award from the Department of Energy (DOE) Office of Science under the Office of Science Financial Assistance Program (CFDA 81.049), effective July 1, 2025, with completion targeted for October 31, 2026. The project, titled "Biocontained Bacterial Spores for Controlled and Durable Plastics Upcycling," supports fundamental scientific research aimed at developing innovative biotechnological...
- Federal Grant Award Summary The University of Delaware received a $186,024 Project Grant award from the National Science Foundation's Division of Emerging Frontiers under the Biological Sciences program (CFDA 47.074), effective September 1, 2025, through August 31, 2028. This collaborative research initiative addresses fundamental questions about how mechanical forces in plant tissues enable growth while maintaining cell-to-cell connectivity. The project delivers integrated research outputs...
- Federal Project Grant Award Summary The University of Delaware received a $430,675 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 15, 2025, with completion targeted for August 31, 2030. The award funds the Corbin Lab's research initiative titled "Probing Spatiotemporal Mechanobiology Through Novel Dynamic Material Platforms," which focuses on developing engineered...
Federal Grant Award Summary The University of Delaware received a $1.0 million Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074), effective July 1, 2026 through June 30, 2029. This research initiative, titled "Tools4Cells: Multi-Kingdom Acetyl-CoA Sensing for Real-Time Reporting and Control of Metabolism," develops protein-based biosensor technology to enable real-time monitoring of acetyl-coenzyme A (acetyl-CoA) levels in microorganisms. The project will create conditional split fluorescent reporters and dCas9 transcriptional regulators responsive to intracellular acetyl-CoA concentrations, allowing dynamic regulation of metabolic pathways for improved production of high-value chemicals in bioproduction systems. The research deliverables include engineered protein variants activated by varying acetyl-CoA levels to provide broader control of pathway efficiency, with demonstration of the technology in both Escherichia coli and Yarrowia lipolytica to establish broad utility and transferability across multiple organism types. The project addresses fundamental questions about metabolic control and regulation while supporting educational outreach activities to local high schools through existing University of Delaware programs. The biosensor technology is expected to facilitate deeper understanding of acetyl-CoA's physiological roles and have significant applications across multiple cell types and organisms.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 6/25/26 |