Project Grant 2535756
- Federal Project Grant Summary The University of Delaware received a $392,495 Project Grant award dated July 1, 2026, from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports fundamental research into the mechanisms of extracellular vesicle (EV) biogenesis and uptake through February 28, 2031. The project delivers research findings and novel methodological tools that advance understanding of how...
- Federal Grant Award Summary The University of Delaware received a $1.0 million Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074), effective July 1, 2026 through June 30, 2029. This research initiative, titled "Tools4Cells: Multi-Kingdom Acetyl-CoA Sensing for Real-Time Reporting and Control of Metabolism," develops protein-based biosensor technology to enable real-time monitoring of...
- Federal Grant Award Summary The University of Delaware received a $186,024 Project Grant award from the National Science Foundation's Division of Emerging Frontiers under the Biological Sciences program (CFDA 47.074), effective September 1, 2025, through August 31, 2028. This collaborative research initiative addresses fundamental questions about how mechanical forces in plant tissues enable growth while maintaining cell-to-cell connectivity. The project delivers integrated research outputs...
- Federal Grant Award Summary The University of California, Davis received a $400,000 Project Grant award from the National Science Foundation (NSF) Division of Biological Infrastructure under the Biological Sciences program (CFDA 47.074), effective August 1, 2026 through July 31, 2029. This collaborative research initiative develops innovative biotechnology tools for targeted proximity labeling of extracellular vesicles (EVs) with fluorescence and biotin tags. The primary deliverables include two...
- Federal Project Grant Award Summary The University of Delaware received a $300,000 Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (Engineering program, CFDA 47.041) effective September 1, 2025, through August 31, 2027, to develop synthetic biology tools for controlling macrophage immune cell phenotype through histone lactylation modulation. The primary deliverables include precision engineering tools—lactylation...
- Federal Grant Award Summary The University of Delaware received a $279,964 Project Grant from the National Science Foundation (NSF) Directorate for Engineering (CFDA 47.041) effective September 1, 2026 through August 31, 2029. This collaborative research award supports the development of predictive computational models that characterize how the mechanical properties of soft nanoparticles interact with cell membrane mechanics to determine cellular uptake pathways. The primary deliverable is a...
- Federal Project Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded the University of Delaware a $1.45 million Project Grant (CFDA 47.074 – Biological Sciences program) effective September 1, 2026, through August 31, 2029, to investigate post-transcriptional regulation of cell division during early embryonic development. The research focuses on how microRNA-1 (mir-1) regulates mitosis and chromosomal segregation using sea urchin embryos...
- The National Science Foundation awarded a $365,567 Project Grant to the University of Delaware under the Biological Sciences federal grant program (CFDA 47.074). The funding will support the acquisition of a Sartorius Biolayer Interferometer Octet RH16 instrument for label-free detection of biomolecular interactions. The instrument will be used broadly in research and undergraduate training programs across multiple campuses, including the University of Delaware and surrounding Primarily...
- Federal Grant Award Summary The University of Delaware received a $876,000 Project Grant award from the Department of Energy (DOE) Office of Science under the Office of Science Financial Assistance Program (CFDA 81.049), effective July 1, 2025, with completion targeted for October 31, 2026. The project, titled "Biocontained Bacterial Spores for Controlled and Durable Plastics Upcycling," supports fundamental scientific research aimed at developing innovative biotechnological...
- Federal Grant Award Summary The University of Delaware received a $2.4 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 1, 2025, with a completion date of May 31, 2030. This Phase III Center of Biomedical Research Excellence (COBRE) award supports the continued discovery and development of chemical probes and lead molecules for biological research and therapeutic...
Federal Grant Award Summary The University of Delaware received a $500,000 Project Grant from the National Science Foundation's Division of Biological Infrastructure under the Biological Sciences program (CFDA 47.074), effective August 1, 2026 through July 31, 2029. This collaborative research award supports the development of innovative biotechnology tools for targeted proximity labeling of extracellular vesicles (EVs)—membrane-bound particles released by cellular organisms that carry biological information. The project will deliver two primary products: (1) a fluorescent labeling tool that enables real-time visualization of EVs upon arrival at their destination via microscopy, and (2) a biotin-conjugating tool that allows researchers to characterize and isolate specific EV subsets for detailed analysis. These tools activate only when EVs reach their intended destination, addressing a significant gap in current scientific capabilities. The research team will apply these tools to investigate how the fungal crop pathogen Colletotrichum uses EVs to infect plants and how plants utilize EVs to mount defensive responses against fungal infections. Beyond the immediate agricultural application, the broadly applicable EV-labeling technologies are expected to have utility across human health, animal biology, and the bioeconomy. The award includes workforce development components consisting of an annual training workshop on EV-related techniques for external scientists and public engagement through demonstrations using portable paper microscopes (Foldscope), alongside interdisciplinary student and early-career researcher training in molecular biology, biochemistry, advanced microscopy, and artificial intelligence-enabled image analysis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $500.0k | 7/13/26 |