Project Grant 2533067
- This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
- This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
- The National Science Foundation (NSF) awarded a $550,000 Project Grant under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Clemson University. The grant, awarded on August 15, 2024, with a completion date of January 31, 2026, funds the development of a novel, automated microwave system for comprehensive single-cell measurement and characterization of high-performing, stable Chinese Hamster Ovary (CHO) cells. The key products and services to be delivered through this...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $574,808 to Duke University over 5 years to study the origins of cellular heterogeneity in T-cell therapies. The research leverages cutting-edge technologies like spatial proteomic multiplexed imaging, in vitro cell tracking, and engineered biomaterial artificial antigen-presenting cells to better understand how single-cell variability arises during the growth and modification of...
- Duke University was awarded a three-year, $750,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences federal grant program (CFDA 47.074). The grant aims to support research transitioning from single-molecule force spectroscopy to single-particle cryogenic electron microscopy. The Biological Sciences program seeks to promote advancement in the biological sciences and strengthen the national scientific enterprise through...
- This $500,000 federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049), supports research to develop a mathematical framework for understanding how porous materials can enhance the efficiency of viral transduction in engineered cell therapies. The award was granted to North Carolina State University (UEI: U3NVH931QJJ3) and will run from September 1, 2025 to August 31, 2028. The key objective of this project is to...
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $730,000 to the University of California, Los Angeles (UCLA) aims to transform the field of protein engineering through the development of an innovative technology called PicnnnShells. PicnnnShells are tiny, hollow particles that can rapidly screen up to one million different protein variations in a single day to identify useful proteins for research, industrial or medical applications. The...
- The National Science Foundation (NSF) awarded a $300,000 Project Grant under CFDA 47.041 (Engineering) to Northwestern University to research and develop engineered virus-like particles (eVLPs) for drug delivery applications. The objective is to understand how cells produce and assemble eVLPs, which mimic the delivery properties of viruses but cannot replicate or cause infection. The project will also create teaching materials integrating biology, biochemistry, engineering, and computational...
- This $500,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), will support research to develop an end-to-end continuous manufacturing process for cell therapies using robotics and microfluidic technologies. The Georgia Tech Research Corporation will receive funding to create a more integrated workflow based on microfluidic device-enabled genetic engineering, cell expansion, and...
- This Project Grant award from the National Science Foundation's Social, Behavioral, and Economic Sciences (CFDA 47.075) program provides $250,000 to Old Dominion University Research Foundation (ODURF) to develop low-cost mRNA-based manufacturing technologies for Chimeric Antigen Receptor (CAR) T-cell therapies. The research aims to address critical issues with current CAR T-cell manufacturing, including safety concerns with viral gene transfer and high costs associated with centralized...
This federal Project Grant award, funded by the National Science Foundation's Biological Sciences program (CFDA 47.074), supports the development and characterization of completely synthetic cell culture media enabled by VHH (nanobody) growth factor alternatives. The $412,750 award to Duke University aims to engineer novel VHH-peptide fusion molecules that can activate cell growth receptors, such as FGFR and EGFR, as cost-effective and tunable alternatives to traditional animal-derived growth factors. The 2-year project, beginning August 2025, will leverage a microbial production system to prototype and manufacture these VHH growth factor alternatives at significantly reduced costs compared to conventional methods. The project outcomes are expected to advance cell culture techniques with broad impacts on human health, sustainable food production, and U.S. biomanufacturing competitiveness.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $412.8k | 8/15/25 |