Project Grant 2532737
- This NSF-BSF Project Grant, awarded by the National Science Foundation (CFDA 47.041 - Engineering), will investigate the role of gut microorganisms in controlling human health by focusing on their interactions with the gut sugar polymer mucin. The $450,000 award, running from September 1, 2025 to August 31, 2028, will utilize miniaturized models of synthetic gut bacterial communities to explore how beneficial and pathogenic bacteria modify the gut mucin layer, which is essential for...
- This $484,314 Project Grant was awarded by the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074). The funding will support research at Christopher Newport University to investigate the "microbiota-gut-brain axis" and the impact of intestinal barrier dysfunction on aging and neurodegeneration. Key objectives include gaining insights into the cellular and molecular changes associated with an aging gut, how...
- This $671,681 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research on bacterial extracellular vesicle (BEV) biogenesis and function within the human vaginal microbiome. The project aims to characterize BEV production, evaluate how mucus impacts BEV transport, and determine how BEV signaling is affected in physiologically relevant environments. The research will advance the fundamental understanding of cross-kingdom cellular...
- This federal Project Grant award of $914,479 from the National Science Foundation's Biological Sciences (CFDA 47.074) program will fund a research project by The Trustees of Columbia University in the City of New York, titled "Elucidating Principles of Microbiome Spatial Organization Using Synthetic Gut Communities." The project aims to analyze factors important for the assembly and stability of microbial communities in the human digestive tract, which are essential for human health...
- This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support a $1,958,603 research project at the University of California, Santa Cruz (UCSC) from August 1, 2025 to July 31, 2029. The project aims to explore whether human brain organoids, lab-grown tissue models of the human brain, can perform computations similar to artificial intelligence (AI) systems. The research team will design new tools to allow the brain organoids to...
- This Project Grant award of $270,000 from the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program funds a Postdoctoral Research Fellowship in Biology for FY 2025-2029. The fellowship supports research and training that will contribute to innovative advances in biology. The key focus of the project is to elucidate the chemical potential of the small intestinal microbiome. It aims to characterize how individual microbes and microbial communities in the small...
- This $2,249,999 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) will fund research to develop new sensing technologies for use in 3D cell cultures using cells from the nervous system. The objective is to create manufacturable 3D mammalian cell culture systems focusing on neural organoids with incorporated sensing technologies. Key research goals include: (1) building and testing conformal microelectrode arrays to interrogate neural organoids...
- The National Science Foundation awarded a $996,521 project grant under the Biological Sciences program (CFDA 47.074) to the Carnegie Institution of Washington for the period of April 1, 2021 through March 31, 2024. The goal of the research project is to scale single-cell physiology studies to better understand community stability in the natural gut microbiome. As part of this work, Johns Hopkins University will expand its microbiome curriculum to additional middle schools in Baltimore County...
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $900,000.00 to Colorado State University (CSU) aims to develop a novel microbiome modeling platform. The platform will integrate omics data, thermodynamics principles, metabolic models, and artificial intelligence to unravel the metabolism, interactions, and evolution of microbiomes. This research will be applied to address specific questions regarding the microbiome of a "rewired...
- This NSF Biological Sciences (CFDA 47.074) Project Grant award of $600,000 to Emory University will investigate how microbiome communities, which are communities of bacteria and other microbes that live in and on organisms, can resist change and transition to alternate states. The project will use the nematode worm Caenorhabditis elegans as a model host to better define the stability and properties of alternate microbiome states, as well as how factors like antibiotic treatment and host...
This federal Project Grant award, provided by the National Science Foundation's Engineering program (CFDA 47.041), aims to develop a new on-chip reductionist model to evaluate the role of gut microbiota and its interactions with in vitro brain models through an in vitro blood-brain barrier (BBB). The $552,957 grant, awarded on October 15, 2025, with a completion date of September 30, 2028, will enable researchers at Iowa State University to study the mechanisms of organ development, cellular interactions, and disease model progression under the influence of the microbiota. The goal is to provide deeper insight into the microbiota-gut-brain axis, which plays a role in neurodegenerative processes, using an alternative in vitro platform rather than relying on animal models or clinical trials. The project also integrates research with education to train undergraduate and graduate students in interdisciplinary studies, producing the next generation of bioengineers.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $553.0k | 8/18/25 |