Project Grant 2531171
- The National Science Foundation (NSF) awarded a $1,199,997 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Colorado-Denver. The grant will fund research to improve understanding of the mechanisms underlying messenger RNA (mRNA) localization and translation, and develop machine learning models to better predict protein production from mRNA. The project will apply recent advancements in RNA sequencing technology to study how factors like tRNA abundance and...
- This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences CFDA program (47.074), will investigate a novel regulatory mechanism called "RNA buffering" that maintains messenger RNA (mRNA) levels despite changes in synthesis and decay rates. The $749,978 project at the University of Utah will explore the protein-protein and protein-RNA interactions involved in this process, which challenges...
- The National Science Foundation awarded a $276,000 Project Grant to an individual located in Seattle, Washington under the Biological Sciences federal grant program (CFDA 47.074). The two-year award will fund research defining the link between genetic variation in human populations and messenger RNA stability. The fellow will use high-throughput experimental and computational approaches to identify amino acid motifs that alter mRNA stability. This includes a novel massively parallel knock-in...
- This $900,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project led by North Carolina State University to unravel the mechanisms behind the workings of the DNA mismatch repair systems. The research aims to elucidate the role of atypical nucleic acid structures, such as three-way junctions and R-loops, in driving the expansion of simple sequence repeats (SSRs) within the genome, which is a...
- Through a $501,868 Project Grant from the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences program (CFDA 47.074), Georgia College & State University will investigate the structural regulation of cap-independent translation in eukaryotic messenger RNA (mRNA). The project aims to bridge critical gaps in understanding how mRNA molecules operate differently under cellular stress conditions compared to normal conditions. Undergraduate researchers at Georgia...
- The National Science Foundation awarded a $1,109,203 Project Grant to The Research Foundation For The State University Of New York to elucidate the role of protein arginine methylation in regulating RNA-binding protein function from May 2021 through April 2025. This award supports research under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the Nation's scientific enterprise through increasing scientific knowledge and...
- This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $796,823 to the University of Missouri System to conduct research on the genetic and molecular mechanisms behind meiotic silencing by unpaired DNA. The research aims to better understand how organisms use RNA-based gene silencing systems to identify and suppress the expression of DNA segments lacking a pairing partner, which can indicate the presence of viruses or...
- This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $949,953 Project Grant to the Research Foundation Of The City University Of New York, doing business as Rfcuny - Hunter College, from August 1, 2023 to July 31, 2026. The grant, funded under the Biological Sciences program (CFDA 47.074), will support research to identify molecular interactions and build a detailed model of translational regulation, specifically examining the role of eIF3 and 4E-BP in...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) in the amount of $800,000.00 aims to dramatically expand the understanding of RNA modification enzymes (RMEs) - a class of proteins that chemically alter RNA molecules and influence their function, stability, and therapeutic potential. The project will systematically identify and assay over 750 RMEs from nearly 100 microbial organisms to establish foundational knowledge and resources to...
This $1,014,796 Project Grant awarded by the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at Case Western Reserve University to investigate the molecular interactions required for targeting defective messenger RNA (mRNA) for degradation through the nonsense-mediated mRNA decay (NMD) pathway. The project aims to uncover previously uncharacterized events that occur between the translation machinery and mRNA surveillance components necessary to target faulty mRNA for rapid degradation, a critical quality control process. This work will leverage innovative genetic and biochemical approaches in the yeast model system to define how the key NMD effector UPF1 interacts with prematurely terminating ribosomes to trigger mRNA decay, and the contributions of NMD cofactors UPF2 and UPF3 to this process. The research will provide research experiences for students at multiple educational levels and broadly disseminate findings to scientific communities and the public.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 8/14/25 |