This federal Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research (CFDA 93.393) program provides $635,033 in funding to The Johns Hopkins University to advance research on the genetic basis of a cancer-prone syndrome caused by long telomere length.
The research aims to identify additional novel mechanisms for the long telomere syndrome, with the goal of detecting high-risk populations who would benefit from screening and surveillance. The proposed studies will define the role of genetic variants in familial cancer predisposition and examine how they disrupt normal telomere length regulation. Building on previous research, the project will also investigate how the long telomere background influences cancer somatic landscapes. This work promises to uncover large-effect size cancer-predisposing variants and define their underlying mechanisms in relevant models, with the potential to inform early detection and prevention protocols. The award period runs from March 10, 2025 to February 28, 2030.
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