Project Grant 2530163
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) provides $847,599 to Arizona State University to conduct collaborative research on the structural and functional mechanisms of a molecular conveyor belt machinery that drives bacterial gliding motility. The research integrates expertise in genetics, biophysics, and cryo-electron tomography to explore how multiple rotating motors on the bacterial surface coordinate to drive a...
- This $265,007 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support collaborative research to advance the understanding of bacterial swimming motion. The research aims to leverage robophysical modeling techniques from robotics to realistically emulate and study the complex interplay of physical and biological factors governing bacterial motility behaviors. Key objectives include elucidating how fluid mechanical forces shape the ways...
- The National Science Foundation (NSF) awarded a $626,831 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Wisconsin-Milwaukee (UWM) to conduct collaborative research on the molecular mechanisms behind how certain bacteria use light-sensing proteins called phytochromes to regulate essential developmental processes. The project aims to use advanced structural biology techniques like cryo-electron microscopy and time-resolved X-ray crystallography to study...
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $373,168 supports collaborative research between the University of Wisconsin-Milwaukee and Northeastern Illinois University to understand the molecular mechanisms behind how myxobacteria use phytochromes to sense light and convert that signal into developmental changes, such as fruiting body formation. The research will utilize cutting-edge techniques including time-resolved X-ray...
- This National Science Foundation (NSF) Project Grant award under CFDA Program 47.041 - Engineering, in the amount of $232,786, will support collaborative research on robophysical modeling of bacterial swimming motion. The project aims to advance the understanding of how fluid mechanical forces shape the ways bacteria navigate their complex environments and interact with each other. By adopting techniques of robophysical modeling, the researchers will isolate physical effects governing...
- This Project Grant award, totaling $30,000.00, was provided by the National Science Foundation's (NSF) Social, Behavioral, and Economic Sciences (CFDA 47.075) program to Northwestern University. The award will support collaborative research to investigate the structural and metabolic dynamics of evolutionarily distinct bacterial microcompartments from September 1, 2025 to August 31, 2028. The research aims to provide a generalizable understanding of how bacterial microcompartments, which allow...
- This National Science Foundation project grant of $512,676 will fund research at Duke University from August 2022 to July 2025 under the Biological Sciences program (CFDA 47.074). The research aims to advance understanding of mechanosensitive channels in bacteria through single-molecule force spectroscopy experiments using an atomic force microscope. Investigators will observe the opening of individual mechanosensitive channels in living E. coli and B. subtilis bacteria in response to mechanical...
- The National Science Foundation (NSF) awarded a $195,656 Project Grant under its Engineering program (CFDA 47.041) to the University of Cincinnati for a collaborative research study on the collective dynamics of multiple bacterial flagella. This 3-year project, starting on July 1, 2024, aims to understand how the flagellar filaments of peritrichous bacteria, such as E. coli, synchronize and rotate collectively to enable swimming in fluid media. The research will integrate macroscopic model...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $410,000 in funding to the University of Chicago to conduct research on bacterial secretion systems using cryo-electron tomography. The key objectives are to: Investigate the assembly, disassembly, and function of bacterial flagellar motors (type III secretion systems) and type IV secretion systems, which are involved in...
- This Project Grant award of $876,272.00 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund collaborative research to develop advanced genetic manipulation tools for bacteria. The project aims to expand the biotechnological capabilities of marine bacteria called Vibrios, which are important in food production, disease, and host-microbe interactions. The research will focus on scaling up methods to influence the expression of individual bacterial genes...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) federal Project Grant award provides $501,879.00 to the University of Chicago to conduct collaborative research on the structural and functional mechanisms of a molecular conveyor belt machinery that drives bacterial gliding motility. The project aims to determine how multiple rotary motors on the bacterial surface coordinate to propel a protein-based conveyor belt, enabling cell movement analogous to a molecular snowmobile. The research integrates work in genetics, biophysics, and cryo-electron tomography to uncover the fundamental structure and mechanical principles underlying bacterial gliding, with potential applications in bio-inspired technological innovations and soft material robotics. The project also involves collaborating with the Arizona State "Ask a Biologist" program to develop interactive online educational tools to enhance public understanding and student engagement in microbiology. The award period is from September 1, 2025 to August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $501.9k | 8/18/25 |