Project Grant 2528103
- This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) will enable Florida International University to develop a new sensing mechanism and approach for a nanopore sensor. The $442,106 award, granted on May 15, 2025, will support research to create an ultrasensitive and selective nanopore sensor capable of detecting and analyzing label-free small molecules, such as adenosine triphosphate (ATP), hormones, neurotransmitters, and pharmaceutical drugs, under...
- The National Science Foundation (NSF), under its Engineering program (CFDA 47.041), awarded a $429,832 Project Grant to the University of Massachusetts (UMass) to develop a novel method for rapid and sensitive detection of nucleic acids such as DNA and RNA. The main objectives of the 5-year project are to: Determine the nanomechanoelectrical transduction principle of nucleic-acid nanostructures tethered to a graphene transistor and oscillating in an electric field. Achieve rapid,...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award for $275,000 will support the development of a plasmonic nanopore sensor device for quality control of adeno-associated viruses (AAVs) used in gene therapy. The proposed device will enable accurate characterization of AAV payload (single-stranded DNA, double-stranded DNA, or empty) at low, pre-scale-up concentrations to optimize formulations. The project aims to demonstrate the...
- The National Science Foundation (NSF) awarded a $475,000 Project Grant under the Engineering program (CFDA 47.041) to the University of California, Irvine (UC Irvine) to design solid-state nanopore systems whose local pore openings are subjected to controllable fluctuations. The research aims to reproduce the fluctuations of biological channels in model systems to understand transport properties on the nanoscale and harness new transport properties that result from these dynamic systems. The...
- This $430,785 National Science Foundation (NSF) CAREER award to the Regents of the University of California at Riverside (UC Riverside), awarded under the NSF Engineering program (CFDA 47.041), is focused on developing novel CRISPR-based biosensing technologies for the ultra-accurate detection of disease-related single nucleotide polymorphisms (SNPs). The central goals of the 5-year project are to: 1) enable ultra-accurate SNP detection using a CRISPR-Cas14 biosensor, 2) design a ratiometric SNP...
- This $475,670 CAREER Project Grant awarded by the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041) aims to develop a new method for tracking molecular changes in live tissue over time. The project will focus on creating a nanostructure-based system to continuously monitor cellular activity and interactions, which can help improve understanding of cellular behavior and advance medical treatments, particularly for complex...
- This Project Grant award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) provides $305,000.00 to Primary Bioscience, Inc. to develop an ultra-sensitive biosensor capable of protein analysis at single-molecule resolution. The biosensor consists of a nanopatterned chip overlayed with a proprietary scaffold material that binds and immobilizes molecular targets, enabling their detection via surface-enhanced Raman spectroscopy. This technology aims to...
- This Project Grant award of $332,826 from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) is funding the development of a compact digital biosensing system enabled by localized acoustic streaming at Lehigh University. The overarching goal is to create a new high-performance, portable diagnostic testing platform that can detect low-abundance biomarkers without requiring dedicated lab equipment or facilities. The proposed method leverages vibrating capillaries and...
- The National Science Foundation awarded a $359,348 Project Grant to the University of Texas at Austin under the Engineering program (CFDA 47.041) for research titled "COLLABORATIVE RESEARCH: ULTRASENSITIVE NUCLEIC ACID SENSING TOOLS BASED ON CAS ASSAYS AND SOLID-STATE NANOPORES." The three-year award beginning March 1, 2021 will support the development of new nucleic acid sensing technologies using Cas assays and solid-state nanopores with the goal of improving detection...
- This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...
This CAREER award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports an integrated research and education project to address fundamental and applied challenges in solid-state nanopore-based single molecule counting platforms for point-of-care nucleic acid testing. The $435,054 award, effective from January 1, 2025 to May 31, 2026, aims to develop a fully integrated solid-state nanopore digital counting system for decentralized nucleic acid testing applications across infectious disease, food safety, and homeland security. The project seeks to overcome key translation challenges with solid-state nanopore sensors, including reproducible size control, introducing specificity, prolonged sensing time at low analyte concentrations, and integrated sample preparation. The research activities will be synergistically integrated with educational efforts to inspire and train future STEM leaders while increasing public awareness of biosensing devices and their societal impacts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $435.1k | 3/31/25 |