This $228,697 National Science Foundation award under the Engineering program (CFDA 47.041) will support the development of an optical biosensor technology to facilitate drug screening and validation efforts. Auctus Biologics, Inc. will utilize a proprietary temperature, pH, and chemically stable protein composed of two fragments that bind with antibody-like affinity and specificity. Over the one-year period ending January 2023, the company will establish the technology's suitability for...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $295,561 to Biosensing Instrument Inc. to develop a commercial prototype of their Plasmonic Scattering Microscopy (PSM) technology. The PSM system aims to enable high-throughput, label-free quantification of membrane protein binding kinetics on single cells in their native cellular microenvironment. This represents a...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology by Biosensing Instrument Inc. The SFNOA system aims to enable high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The $349,566 award, effective from April 2, 2025 to March 31, 2026,...
This National Science Foundation (NSF) CAREER award, under CFDA 47.041 Engineering, provides $242,687 to the University of Massachusetts to develop a next-generation nanopore biosensor technology for ultrasensitive, multiplex detection and quantification of infectious disease biomarkers at the point-of-care. The key objectives are to: (1) optimize a highly sensitive, robust, and reproducible nanopore biosensor; (2) enable sensitive and specific biomarker detection through automated...
This $442,106 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports the development of a new ultrasensitive, label-free nanopore sensor for detecting and analyzing small molecules, including biomolecules and bioactive compounds, at the single-molecule level under physiological conditions. The project aims to leverage self-crowding and ligand-binding phenomena at the nanopipette tip to enable highly sensitive and selective detection of small...
This $275,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program supports the development of a label-free, high-resolution, high-throughput protein screening platform called Vibrational Spectroscopy with Metasurface Optics (VISMO). The technology aims to enable simultaneous, minute-scale measurement of millions of protein samples, which would dramatically improve the lengthy and costly cycles...
The National Science Foundation awarded Integrated Medical Sensors Inc. a $256,000 Project Grant under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a novel multi-analyte microsensor platform for continuous wireless monitoring applications. The grant aims to create a unique monolithic semiconductor platform capable of wirelessly monitoring multiple biochemical and physiological markers simultaneously in a sub-cubic millimeter footprint. This miniature,...
This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...
This $350,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development and demonstration of a novel, enzyme-based, single-molecule protein sequencing system by Electronic Biosciences, Inc. The innovative platform aims to leverage enzymatic processing and advanced bioinformatics to enable scalable, multiplexed protein sequencing with high accuracy and throughput. During this Phase I...
This $495,516 Project Grant, awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041), aims to develop a next-generation, ultrasensitive, and easy-to-use diagnostic platform for detecting nucleic acids as biological markers for diseases and pathogens. The key innovations focus on: (1) signal amplification through redox-tagged reporter aptamers in a graphene microstructure array; (2) enhancing charge transfer kinetics through plasma-induced graphene...