This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $322,978 to the University of Wisconsin System to develop and optimize a novel protein degradation tool called E3-DART for use in plant biology research. The key objectives are to: 1) create a ligand-inducible version of the E3-DART system, 2) combine E3-DART with other recombinant tools to control its activity, and 3) demonstrate proof-of-concept applications of E3-DART for studying endomembrane protein function and secretory protein trafficking in plant cells. This research aims to provide a robust system for controlling protein abundance in plants, which will enable deeper insights into dynamic cellular processes not possible with existing tools. The award period runs from the start date of Dec 15, 2024 through the ultimate completion date of Nov 30, 2026. No subawards are planned under this grant.
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