Project Grant 2526692
- This $414,285 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental research into the dynamic pattern formation and self-organizing behaviors of the cell cortex. The research aims to elucidate the principles underlying cortical reorganization processes that drive critical cellular functions like cell division, locomotion, and damage response. The primary awardee is the...
- This four-year Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences provides $835,577 to support research titled "Synthetic Control of Pattern Formation and Morphogenesis in a Purposefully Rewired Vertebrate Cell." The grant will fund basic research under the Biological Sciences program (CFDA 47.074), which aims to advance understanding of major biological problems and strengthen the nation's scientific enterprise. Specifically, the...
- This federal Project Grant award of $946,895 from the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences (CFDA 47.074 Biological Sciences) will fund research to advance the understanding of protein phosphorylation and its role in coordinating cell division. The project aims to identify new enzymes that carry out phosphorylation and the substrate proteins they modify to ensure proper cell division. Researchers will employ computational, biochemical, proteomic,...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $629,896 Project Grant to the University of Wisconsin-Madison on February 15, 2021 with a completion date of January 31, 2026. The grant supports research under the Biological Sciences program (CFDA 47.074) to advance understanding of heterogeneous decision-making in individual microbes and populations through synthetic approaches. As the official program description indicates, the Biological Sciences...
- This $1,269,993 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to understand the molecular basis of how plant cells establish the division plane during cell division. The project aims to dissect the function of cytoskeletal motor assemblies at the cortical division site and determine how they connect to molecules in the phragmoplast, the structure that forms the new cell wall during cytokinesis. Researchers at...
- This National Science Foundation (NSF) federal Project Grant award under the Biological Sciences program (CFDA 47.074) is funding the University of Illinois to construct a new type of self-replicating synthetic cell system. The $448,355 award from June 1, 2024 to May 31, 2027 supports the development of engineered synthetic cells that can grow, divide, and replicate their genetic information using nucleic acids as both structural and genetic components. The project aims to investigate the...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $949,997 Project Grant to the University of Wisconsin-Madison under the Biological Sciences federal grant program (CFDA 47.074). The grant will fund research from July 2021 through June 2025 to advance understanding of plant endosomal sorting mechanisms and ESCRT function in plants. As the stated purpose of the Biological Sciences program is to promote progress in biology and strengthen the national...
- This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
- This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $372,100 to the University of Wisconsin - Madison to develop novel "mechanoimaging" technologies that can measure and program piconewton-scale mechanical forces exerted by individual cell receptors in viscoelastic biomaterials. The goal is to quantify how cells, including fibroblasts, cancer cells, and T cells, physically...
This Project Grant award of $803,678 was provided by the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program to the University of Wisconsin System (UW System) from August 15, 2025 through July 31, 2029. The objective of the project is to use synthetic proteins and artificial intelligence to better understand crucial cell division events at the cell cortex, with the goal of addressing pathologies like cancer, impaired healing, infertility, and abnormal development that arise when cell division goes awry. The research will focus on understanding how Rho GTPases self-organize into cortical patterns that drive formation of the contractile machinery required for cell division. The project also aims to train high school and college students in synthetic biology, molecular biology, and AI-assisted protein design as part of developing the future scientific workforce.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $803.7k | 8/4/25 |