Project Grant 2525487
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award in the amount of $948,390.00 will fund the development of cell type-specific genetic tools for the freshwater sponge Spongilla lacustris. The project aims to (1) optimize transfection conditions for efficient gene delivery and expression in sponge cells, (2) create a modular plasmid toolkit featuring cell type-specific promoters, fluorescent proteins, and subcellular targeting signals, and (3)...
- This $1,526,917 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) aims to revolutionize the use of poeciliid fish (guppies, mollies, and swordtails) as a model system for genome editing research. The project will develop new biotechnological tools, including immortalized cell lines and CRISPR-based DNA editing protocols, to enable precise genetic modifications in these organisms. In addition, the award will generate high-quality genome...
- This Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program is supporting research to investigate the origin and development of novel traits, specifically focused on the stinging apparatus of cnidarians (e.g., corals, jellyfish). The $230,000.00 award to Cornell University, which began on Mar 15, 2025 and is set to conclude by Feb 28, 2030, aims to characterize the protein-protein interactions necessary for the construction of the...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant award, valued at $570,122.00 and effective September 1, 2024, supports a collaborative research effort to investigate innate immune responses in diverse eukaryotic organisms that consume bacteria. The project brings together a cross-disciplinary team of researchers to study innate immunity in sponges, choanoflagellates, and amoebae, which span the evolutionary transition between multicellular animals and their...
- This Project Grant award of $876,272.00 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund collaborative research to develop advanced genetic manipulation tools for bacteria. The project aims to expand the biotechnological capabilities of marine bacteria called Vibrios, which are important in food production, disease, and host-microbe interactions. The research will focus on scaling up methods to influence the expression of individual bacterial genes...
- This federal Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $1,013,589 to the University of Florida to study the environmental induction of a novel cell type, the amoebocyte, in the upside-down jellyfish Cassiopea xamachana and to investigate the molecular mechanisms behind the establishment of stable photosymbiosis between the host and photosynthetic dinoflagellate algae. The research aims to gain insights into how novel cell...
- This Project Grant award, provided by the National Science Foundation's (NSF) Biological Sciences Program (CFDA 47.074), aims to revolutionize the use of poeciliid fishes (guppies, mollies, and swordtails) as model organisms for genome editing research. The $471,066 award to Texas State University, effective September 15, 2025, through August 31, 2029, will develop new biotechnological tools to enable precise DNA editing in these small, colorful aquarium fish. This will unlock their full...
- Yale University was awarded a $950,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences. The grant is part of NSF's Biological Sciences program (CFDA 47.074) to promote progress in the biological sciences and strengthen the Nation's scientific enterprise. Under the award, Yale University will investigate the molecular mechanism of touch sensitivity in the schnauzenorgan of the elephant nose fish from July 1, 2021 to June 30, 2025. The research...
- This $125,954 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports collaborative research examining the role of mucus in the success and range expansion of Cassiopea jellyfish and related species. Over the two-year award period ending December 2025, the research team will characterize the physical properties of Cassiopea mucus and the motility of plankton and stinging cells within it using mathematical and engineering tools. They will also...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $270,000.00 provides funding for a Postdoctoral Research Fellowship to investigate the genetic program responsible for segment formation in annelid worms and how environmental factors influence segment addition. The fellowship supports research and training to contribute innovative insights into the evolution of animal diversity, with potential applications to fields like regeneration. The project...
This federal Project Grant award, provided by the National Science Foundation's Biological Sciences program (CFDA 47.074), aims to develop a comprehensive toolkit of molecular tools and protocols for visualizing and manipulating gene activity in specific cell types of the freshwater sponge Spongilla lacustris. The $1,051,610 award to Yale University will support efforts to: (1) optimize transfection conditions and create a modular plasmid toolkit with cell type-specific promoters, fluorescent proteins, and subcellular targeting signals; and (2) implement CRISPR/Cas9 genome editing to generate stable transgenic sponge lines. These new research capabilities will empower investigations across developmental biology, immunology, cell evolution, and natural product discovery by transforming sponges into a more accessible model system. The project is expected to run from November 1, 2025 to October 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 8/6/25 |