Project Grant 2525488
- This federal Project Grant award, provided by the National Science Foundation's Biological Sciences program (CFDA 47.074), aims to develop a comprehensive toolkit of molecular tools and protocols for visualizing and manipulating gene activity in specific cell types of the freshwater sponge Spongilla lacustris. The $1,051,610 award to Yale University will support efforts to: (1) optimize transfection conditions and create a modular plasmid toolkit with cell type-specific promoters, fluorescent...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant award, valued at $570,122.00 and effective September 1, 2024, supports a collaborative research effort to investigate innate immune responses in diverse eukaryotic organisms that consume bacteria. The project brings together a cross-disciplinary team of researchers to study innate immunity in sponges, choanoflagellates, and amoebae, which span the evolutionary transition between multicellular animals and their...
- This $1,526,917 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) aims to revolutionize the use of poeciliid fish (guppies, mollies, and swordtails) as a model system for genome editing research. The project will develop new biotechnological tools, including immortalized cell lines and CRISPR-based DNA editing protocols, to enable precise genetic modifications in these organisms. In addition, the award will generate high-quality genome...
- This Project Grant award of $876,272.00 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund collaborative research to develop advanced genetic manipulation tools for bacteria. The project aims to expand the biotechnological capabilities of marine bacteria called Vibrios, which are important in food production, disease, and host-microbe interactions. The research will focus on scaling up methods to influence the expression of individual bacterial genes...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $270,000.00 provides funding for a Postdoctoral Research Fellowship to investigate the genetic program responsible for segment formation in annelid worms and how environmental factors influence segment addition. The fellowship supports research and training to contribute innovative insights into the evolution of animal diversity, with potential applications to fields like regeneration. The project...
- This Project Grant award, provided by the National Science Foundation's (NSF) Biological Sciences Program (CFDA 47.074), aims to revolutionize the use of poeciliid fishes (guppies, mollies, and swordtails) as model organisms for genome editing research. The $471,066 award to Texas State University, effective September 15, 2025, through August 31, 2029, will develop new biotechnological tools to enable precise DNA editing in these small, colorful aquarium fish. This will unlock their full...
- This Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program is supporting research to investigate the origin and development of novel traits, specifically focused on the stinging apparatus of cnidarians (e.g., corals, jellyfish). The $230,000.00 award to Cornell University, which began on Mar 15, 2025 and is set to conclude by Feb 28, 2030, aims to characterize the protein-protein interactions necessary for the construction of the...
- This Project Grant award of $696,819.00 from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports a collaborative research project to investigate innate immune responses in diverse microbial-feeding organisms across the evolutionary spectrum. The project brings together researchers from the University of Pittsburgh, University of Texas at Austin, and other institutions to study how sponges, choanoflagellates, and amoebae - which have high levels of microbial...
- This National Science Foundation project grant award of $138,000 provides funding from November 1, 2022 through October 31, 2024 to support research and training under the Biological Sciences federal grant program (CFDA 47.074). The award will fund a postdoctoral fellowship to investigate how gene-environment interactions have shaped the repeated evolution of differentiated multicellularity. The fellow will employ single-cell transcriptomics and comparative analyses to examine how...
- This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $270,000 in funding from April 1, 2026 to March 31, 2029 to support a postdoctoral research fellowship focused on investigating the eco-evolutionary impacts of cyanobacterial diets on host-parasite interactions. The research aims to uncover the molecular basis for parasite susceptibility in the Daphnia-Metschnikowia host-parasite system and determine if susceptibility is...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award in the amount of $948,390.00 will fund the development of cell type-specific genetic tools for the freshwater sponge Spongilla lacustris. The project aims to (1) optimize transfection conditions for efficient gene delivery and expression in sponge cells, (2) create a modular plasmid toolkit featuring cell type-specific promoters, fluorescent proteins, and subcellular targeting signals, and (3) implement CRISPR/Cas9 genome editing to generate stable transgenic sponge lines. These tools will enable researchers to directly study gene function in sponges, which are important model organisms for understanding the evolution of complexity, specialized cell types, and interactions with microbes. The award will also provide training opportunities to accelerate the adoption of these methods by the broader sponge research community. The project will be carried out by the University of Denver over a period of 4 years from November 1, 2025 to October 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $948.4k | 8/6/25 |