This National Science Foundation Project Grant of $606,649 will support the development of an engineered cyber-physical system combining advanced biological models and artificial intelligence methods to enable precision medicine for cancer treatment. Awarded under the Computer and Information Science and Engineering program, the funding will be used by Brigham and Women's Hospital and its parent organization Partners Healthcare System from October 2022 to September 2025. Specifically, the...
This $280,000 Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program supports the development of comprehensive generative AI methodologies and computational tools to expedite drug discovery, enhance cost efficiency, and improve success rates. The project aims to create a holistic generative AI framework capable of generating high-quality drug candidates with multiple desired properties, with the potential to transform...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Phase I Small Business Technology Transfer (STTR) project grant, awarded to Vivosphere LLC, is developing a novel 3D tissue-engineered platform for cancer modeling and high-throughput drug screening. The $275,000 project aims to create a more physiologically relevant and scalable system to improve the translation of preclinical cancer drug candidates to clinical trials. Key objectives include testing...
This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program provides $365,887 to The Research Foundation For The State University Of New York (RF SUNY) to develop an innovative artificial intelligence (AI) technology to select optimal treatment options for individual cancer patients. The goal is to prolong patient life by tailoring treatments to each patient, which can also reduce healthcare costs by avoiding...
This National Science Foundation Project Grant of $255,995 supported Encapsulate Inc. to develop an automated biochip platform for personalized cancer screening under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). The award period was from May 15, 2022 to April 30, 2023. The platform will grow patient-derived cancer cells outside the body on biochips to screen them against chemotherapy drugs. This addresses the problem that over 70% of cancer patients undergo ineffective...
This $599,486 National Science Foundation award under the Engineering (47.041) program will fund the development of an engineered cardiac tissue model with embedded soft microelectronics for continuous cardiotoxicity screening at The Pennsylvania State University from January 2022 to September 2023. The key product is a 3D-bioprinted, microvascularized cardiac tissue model integrated with stretchable microelectronics to enable real-time, intra-tissue measurement of cardiotoxicity responses to...
This Project Grant award of $305,000.00 from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program aims to revolutionize drug discovery by accelerating molecular dynamics simulations through advanced AI techniques. The project, awarded to Giwotech Inc. in Dorchester, MA, seeks to develop a robust neural network model capable of simulating protein systems up to 500 times faster than current GPU-based classical molecular dynamic simulators while...
This $600,000 Project Grant award from the National Science Foundation's Division of Information and Intelligent Systems (CFDA #47.070 - Computer and Information Science and Engineering) supports the Massachusetts Institute of Technology (MIT) in developing a cyber physical system to remotely control cellular processes and create synthetic pancreatic tissue. The research aims to overcome challenges in recreating complex 3D tissue structures by using swarms of microrobots to regulate the...
This Project Grant award from the National Science Foundation's (NSF) Integrative Activities (IA) program (CFDA 47.083) supports the development of a computational modeling framework that integrates machine learning with first-principles multiscale models. The $245,403 grant awarded to Kansas State University (KSU) will enable an assistant professor and graduate student to collaborate with the Terasaki Institute for Biomedical Innovation to create models that accurately predict disease...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Cerflux Inc. aims to develop a personalized cancer treatment screening platform. The project will establish guidelines for handling solid tumor biopsy samples, generate 3D bioprinted tumor models for validation, and demonstrate the platform's ability to match patients with the most effective cancer treatments before treatment begins. This innovative approach has the...
This Project Grant award of $275,956 from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program aims to develop an engineered cyber-physical system that combines advanced biological models with artificial intelligence methods for predictive, automated screening of anti-cancer drugs and optimization of their dosing.
The key products and services to be delivered under this award include: 1) Adoption of 3D bioprinting to generate vascularized ductal carcinoma and cardiac tissue models, creating a biomimetic human myocardium for evaluating drug toxicity; 2) Adaptation of the bioprinted models to microfluidic systems; 3) Real-time, non-invasive monitoring of biophysicochemical parameters to generate multi-dimensional data for predictive modeling; and 4) Implementation of a novel joint Bayes modeling approach using deep learning to enable self-dose optimization on the organ-on-a-chip platform. This research is expected to advance the realization of the precision medicine paradigm and have significant social impacts by minimizing the use of animals in drug testing.