This National Science Foundation Project Grant of $606,649 will support the development of an engineered cyber-physical system combining advanced biological models and artificial intelligence methods to enable precision medicine for cancer treatment. Awarded under the Computer and Information Science and Engineering program, the funding will be used by Brigham and Women's Hospital and its parent organization Partners Healthcare System from October 2022 to September 2025. Specifically, the investigators will leverage expertise in biofabrication, tissue engineering, microfluidics, bioanalysis and artificial intelligence to develop a multi-organ microfluidic platform for accurately predicting both efficacy and safety of anti-cancer regimens. Key innovations include 3D bioprinting of vascularized models of ductal carcinoma and cardiac tissue, real-time non-invasive monitoring of biophysical and chemical parameters, and a novel joint Bayesian modeling approach implemented through deep learning to enable self-dose optimization on the organ chips.