This Project Grant award from the National Science Foundation's Division of Information and Intelligent Systems (CFDA 47.070 - Computer and Information Science and Engineering) aims to develop a cyber-physical system that uses microrobots to control and direct the differentiation of genetically engineered stem cells to form desired pancreatic tissue. The $499,181 project, which will run from September 1, 2023 to August 31, 2026, focuses on overcoming the challenge of recreating the complex 3D...
This Project Grant award, provided by the National Science Foundation's Engineering program (CFDA 47.041), supports the development of an "Intelligent Liver Organoid" that can learn and adapt to environmental conditions like viral infections and toxins. The project team at the Massachusetts Institute of Technology (MIT) will engineer liver cells to harbor artificial neuronal networks using synthetic gene circuits, and utilize microscale robots to facilitate communication and learning...
This $275,956 federal Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) supports the development of an engineered cyber-physical system that combines advanced biological models with artificial intelligence methods. The goal is to create a platform capable of accurately predicting patient responses to anti-cancer therapies, enabling real-time precision medicine. Key innovations include the use of 3D...
This National Science Foundation Project Grant of $606,649 will support the development of an engineered cyber-physical system combining advanced biological models and artificial intelligence methods to enable precision medicine for cancer treatment. Awarded under the Computer and Information Science and Engineering program, the funding will be used by Brigham and Women's Hospital and its parent organization Partners Healthcare System from October 2022 to September 2025. Specifically, the...
This $200,348 Project Grant awarded by the National Science Foundation (NSF) under the Computer and Information Science and Engineering (CFDA 47.070) program supports the development of modular biological robots with variable morphology. The project aims to create functional modules controlled by different colors of light to enable new capabilities for "biobots" - robots fabricated from biological cells. Key goals include designing biobots that can split apart or join together on...
This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) is supporting a collaborative research effort focused on developing an intelligent lab-on-chip device to monitor and promote the maturation of stem cell-derived cardiomyocytes. The $192,150 award to the New York Institute of Technology (NYIT) aims to create an integrated system that can non-invasively evaluate cardiomyocyte maturity in real-time and adaptively apply electrical and mechanical...
The Massachusetts Institute of Technology (MIT) received a $420,061 Project Grant award from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems on August 1, 2021 to develop nanosensor chemical cytometry (NCC) technologies in support of cellular therapeutics through July 31, 2024. The NSF award supports MIT's work under the Engineering (47.041) federal grant program, which seeks to foster innovation and excellence in engineering...
The Massachusetts Institute of Technology (MIT) received a $400,000 project grant award from the National Science Foundation (NSF) Division of Information and Intelligent Systems on October 1, 2021. The award is part of the NSF's Computer and Information Science and Engineering program (CFDA 47.070) to support collaborative research on computational design of complex fluidic systems through September 30, 2025. Under the award, MIT researchers will work with NSF to advance development of...
This $314,769 Project Grant awarded by the National Science Foundation's Engineering program (CFDA 47.041) supports research that aims to advance the fundamental understanding of how cells and tissues communicate information about their mechanical environment. The award, effective from February 1, 2025 to January 31, 2030, will fund the development of new material platforms based on magnetic materials that can dynamically change local stiffness via magnetic fields. Experiments will explore how...
The National Science Foundation awarded a $367,636 Project Grant to the Massachusetts Institute of Technology from March 1, 2021 through February 29, 2024 under the Biological Sciences program (CFDA 47.074). The grant funds collaborative research on multidimensional single-cell phenotyping to elucidate relationships between genomes and phenotypes. The Biological Sciences program aims to advance biological knowledge and understanding of major problems through basic research. This award supports...
This $600,000 Project Grant award from the National Science Foundation's Division of Information and Intelligent Systems (CFDA #47.070 - Computer and Information Science and Engineering) supports the Massachusetts Institute of Technology (MIT) in developing a cyber physical system to remotely control cellular processes and create synthetic pancreatic tissue. The research aims to overcome challenges in recreating complex 3D tissue structures by using swarms of microrobots to regulate the differentiation of genetically engineered stem cells. The project seeks to enable the reliable and scalable production of human organoids as an alternative to animal testing for drug development and personalized medicine. Broader impacts include increasing underrepresented minority participation in problem-solving research careers. The award period is from September 1, 2023 to August 31, 2026.