This $1,999,998 National Science Foundation Project Grant, funded under the Biological Sciences program (CFDA 47.074), supports research at the University of Washington to advance plant synthetic biology through deciphering the grammar of crop gene regulatory elements. The three-year award beginning March 1, 2023 will apply massively parallel reporter assays and machine learning to characterize tens of thousands of genetic regulatory elements in maize and tomato, including enhancers,...
This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $300,000 in funding to Western University of Health Sciences to conduct collaborative research on the variability and regulation of the plant polyadenylation complex. The research aims to better understand how this complex mediates gene expression and plant responses to environmental and developmental cues, with the goal of improving our knowledge of crop plant growth,...
This $520,720 Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), supports the development of new genetic analysis tools that incorporate molecular and cellular biology knowledge into statistical models for mapping genes, predicting traits, and simulating genotype-to-phenotype relationships. The primary goal is to test emerging genetic models, such as the omnigenic model, and understand how and why genetic architecture differs...
This $249,000 National Science Foundation project grant funds the development of computational and experimental tools to engineer gene expression in rice. Funded under the Biological Sciences program (CFDA 47.074), the award supports a postdoctoral fellowship held by David Ding at the University of California, Berkeley from July 1, 2023 to June 30, 2026. The fellow will create a pipeline to understand regulatory mutations in plants at scale, coupled with high-throughput experimental assays. A...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $794,457 will develop new tools for geneticists to incorporate emerging models of genetics into their research and rigorously test the underlying concepts. The tools will be tested in laboratory plants and crops, which are ideal systems to develop and test concepts and tools that can later be used in hard-to-study organisms like humans or wild organisms. The broader impacts include...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award, totaling $640,474, will fund research to improve nitrogen use efficiency in plants. The project aims to develop novel tools and approaches to engineer plants with improved root systems and nitrogen-responsive traits, which can increase the plants' ability to efficiently uptake and utilize applied nitrogen fertilizers. This will help reduce the environmental impact and costs associated with...
This National Science Foundation Project Grant of $921,054 supports research to develop new biological functions through engineering plant hormone receptors. Led by the Regents of the University of California, Riverside under the Biological Sciences program (CFDA 47.074), the project engineers plant sensors to recognize pharmaceuticals and dietary molecules. It then uses these sensors to design "sentinel cells" that indicate molecule presence through color changes. Specifically, the...
This $998,790 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will support enhancing global plant transformation capacity through research, training, and partnerships led by Boyce Thompson Institute For Plant Research Inc. Over a three-year period, the grantee will establish a global research coordination network to collectively address challenges to plant genetic engineering and gene editing efficiency. The network aims to facilitate...
The National Science Foundation awarded a $999,220 project grant to the University of Oregon on March 15, 2021 with a completion date of February 29, 2024. The grant falls under the Biological Sciences program (CFDA 47.074) to promote progress in the biological sciences and strengthen the nation's scientific enterprise through increasing knowledge and understanding of major problems.
Specifically, the grant funds the "PLANTSYNBIO" project to develop regulatory systems for tuning...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant in the amount of $725,512 aims to develop highly efficient and robust prime editing (PE) systems in rice, tomato, and poplar plants. The project will optimize PE proteins, improve PE guide RNA structure and expression, and modify plant DNA repair systems to increase PE editing efficiency. This cutting-edge CRISPR/Cas-based gene editing technology will enable precise genetic modifications, facilitating...