This Project Grant award of $322,288 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project led by William Marsh Rice University. The project aims to study how microbial symbionts influence the health and population dynamics of their grass host species in response to environmental fluctuations. The research team will use a unique long-term dataset from a symbiont-removal experiment to build stochastic demographic models...
Rice University was awarded a $1,989,933 project grant from the National Science Foundation Division of Emerging Frontiers under the Biological Sciences federal grant program (CFDA 47.074) for the period of October 1, 2021 through September 30, 2026. The grant will support research to elucidate the rules of cooperation and resiliency in microbial communities through stochastic graph grammars. This work aligns with the Biological Sciences program's goals of advancing the biological sciences and...
This National Science Foundation (NSF) Biological Sciences program project grant awarded to William Marsh Rice University (Rice University) in the amount of $800,000 will fund the development of a high-throughput approach to build and study synthetic microbial communities. The project aims to create new methods to rapidly construct and understand the interactions within these complex communities of microbes, with the goal of identifying new sources of antibiotics and providing educational and...
The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $288,550 Project Grant to the University of Rhode Island for research titled "EAGER: MECHANISM OF TOXIN ACTIVATION AND FUNCTION IN BACTERIA." The two-year award running from July 1, 2021 to June 30, 2023 is being conducted under the Biological Sciences program (CFDA 47.074). This grant aims to advance understanding of major problems confronting the nation by supporting basic research into the...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) was made to William Marsh Rice University in the amount of $136,600, with a period of performance from March 1, 2025 to February 28, 2030. The project aims to develop and apply advanced tools to directly visualize, quantify, and correlate DNA dynamics, organization, and gene activity in real-time within human cells. The research will yield insights into how genomic structure,...
This National Science Foundation (NSF) Project Grant under the CFDA program "Biological Sciences" (47.074) is awarded to Trustees of Boston University to develop and optimize optogenetic tools for selecting bacterial cells based on dynamic, time-varying traits. The $796,158 award, effective August 1, 2023 through July 31, 2026, supports the researchers in creating light-inducible genetic constructs that trigger antibiotic resistance, enabling the isolation of bacteria exhibiting...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award, totaling $1,117,922.00, supports research to determine the mechanisms of bacterial tyrosine kinase activation and regulation. The Research Foundation of the City University of New York will utilize computational and experimental methods, including biochemical assays, NMR spectroscopy, and mass spectrometry, to investigate the activation of bacterial BY-kinases in both Gram-positive and Gram-negative...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant award of $600,000 to the Board of Regents of the University of Nebraska aims to identify the antimicrobial molecules produced by the bacterium Pseudomonas protegens PBL3 and understand how they inhibit the growth of the plant pathogen Burkholderia glumae, which causes devastating bacterial panicle blight disease in rice. The project will employ multi-disciplinary approaches including genetics, comparative...
This $300,000 federal Project Grant award under the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will be used by the University of California, Davis (UC Davis) to conduct research on the molecular mechanisms and evolution of Type 6 Secretion System (T6SS) toxins and immunity proteins in phytopathogenic Ralstonia bacteria. The central objective is to understand how these toxin warfare strategies enable Ralstonia to successfully compete against other...
This Project Grant award of $200,055 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Purdue University on the assembly and supramolecular organization of bacterial microcompartments. The research aims to develop a model for how these large protein assemblies are built, mature, and function, with a focus on the carboxysome and propanediol-utilization compartments. The project combines cryo-electron tomography, mathematical modeling, and...