This Project Grant award of $285,630 from the National Science Foundation's Engineering program (CFDA 47.041) will focus on elucidating the molecular mechanisms associated with the development of osteoarthritis. The primary research objectives are to: (1) establish a baseline catabolic threshold for tensile force applied to chondrocyte integrins, (2) determine the degree to which actin dynamics drives chondrocyte preference for dynamic force, and (3) establish surface glycoproteins as modulators...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $618,629 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to The Regents of the University of Colorado to establish a new "microphysiological joint-on-chip" system. The objective is to create a realistic human joint model that can support mechanistic study of arthritic diseases and rapid testing of candidate treatments. The researchers plan to develop...
This $1,016,000 Cooperative Agreement award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of a localized, sustained-release drug delivery platform for treating post-traumatic orthopedic injuries. The project, led by Nostopharma LLC, a woman-owned small disadvantaged business, aims to create a biodegradable nanoparticle formulation containing anti-inflammatory and Hedgehog pathway inhibitor drugs....
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $1,657,392.00 to the University of Pittsburgh to conduct research on repurposing FDA-approved drugs for the treatment of osteoarthritis (OA). The research aims to leverage high-throughput screening in human cell-derived microphysiological models to identify disease-modifying OA drugs...
The University of Rochester received a $475,811 Project Grant award from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation under the Engineering (47.041) federal grant program. The award will fund research from September 1, 2022 through August 31, 2025 to study how the accumulation of macromolecules influences cartilage mechanics and chondrocyte health. Specifically, the university will analyze how the buildup of large soluble molecules within...
This $250,000 National Science Foundation Technology, Innovation, and Partnerships Project Grant supports the development of artificial substrates for growing human stem cells suitable for clinical applications at Oakland University from March 2023 to February 2025. The goal is to accelerate the potential benefits of using human pluripotent stem cells and their derivatives for treating and curing diseases by producing a synthetic substrate that supports growth of human pluripotent stem cells...
This $624,622 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports research to advance the understanding of cartilage microstructure, function, and computational modeling. The 5-year project, starting on September 1, 2025, will leverage quantitative magnetic resonance imaging (MRI) to investigate the relationship between cartilage microstructure, mechanical properties, and bone shape. The research will employ in vivo experiments,...
The University of Connecticut received a $266,000 Project Grant award from the National Science Foundation under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a delivery technology for large messenger RNA (mRNA) applications in cartilage and joint tissues. The university will introduce an innovative platform using DNA-inspired Janus base nanomaterials to help large mRNA enter tissues for biomedical uses from therapeutics to research reagents. Postdoctoral...
The federal Project Grant award R21AR085398, totaling $1,288,152.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award aims to develop a high-throughput screening approach, named "JOINTSEQ", to identify nanoparticles (NPs) that can target specific cell types in osteoarthritis (OA) joints. The research team, led by Tufts University School of...
This Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Orthomechanica, Inc., a small minority-owned business located in Corvallis, OR. The funding supports the design, engineering, and preclinical validation of a novel implantable medical device that aims to improve functional outcomes for over 100,000 patients annually undergoing reconstructive surgery. The device integrates a...