Project Grant 2517098
- This Project Grant award from the National Science Foundation (NSF) Division of Chemistry supports a collaborative research project between Drs. Harish Vashisth from the University of New Hampshire and Esteban A Orellana Vinueza from Dartmouth College. The $320,000 award, with a project period from September 1, 2025 to August 31, 2028, aims to study how chemical modifications to nucleic acid bases affect the structure, folding, and dynamics of transfer RNA (tRNA) isodecoders. The project applies...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded a $1,050,000 Project Grant to Princeton University to deepen the understanding of chemical modifications on ribonucleic acid (RNA) and their role in biological processes. The 3-year project, titled "Illuminating the Dihydrouridine Epitranscriptome," aims to characterize the RNA modification dihydrouridine (D) and its writer enzymes, as well as elucidate their biological function...
- The National Science Foundation (NSF) Division of Chemistry awarded a $500,000 Project Grant titled "TOPICS IN PROTEIN AND RNA FOLDING AND DYNAMICS" to the University of Texas at Austin under the Mathematical and Physical Sciences program (CFDA 47.049). This 4-year grant will support Professor Devarajan Thirumalai's research on the computational modeling of protein and RNA interactions and dynamics. Key focus areas include developing new methods to simulate intrinsically disordered...
- The National Science Foundation (NSF), through its Mathematical and Physical Sciences program (CFDA 47.049), has awarded a $749,999 Project Grant to Princeton University and San Diego State University. The grant will fund the development of a novel method for tracking the synthesis, localization, and dynamics of RNA messages in living cells using metabolically incorporated fluorescent nucleosides. This innovative approach will enable researchers to study the organization of cellular structures...
- The National Science Foundation (NSF) Division of Chemistry awarded a $1,500,000 Project Grant to Stanford University under the Mathematical and Physical Sciences (MPS) program (CFDA 47.049). The grant, awarded on March 1, 2024, supports a 3-year research project titled "Evaluating and Advancing Cryo-EM for RNA Conformational Ensembles." The project aims to: (1) design, model, and experimentally probe RNA systems with discrete conformational states, and (2) characterize and challenge...
- The National Science Foundation (NSF) awarded a $600,000 project grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the Research Foundation of the City University of New York (RFCUNY) to support Professor Mahesh Lakshman's research on developing novel chemical methods for modifying nucleosides. Nucleosides are the fundamental building blocks of DNA and RNA, and this research aims to obtain a better understanding of chemical processes to enable selective modifications...
- This $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will support research into the structural biology of RNA and RNA-protein interactions through May 2024. Funded under the Biological Sciences program (CFDA 47.074), this award to Vanderbilt University will utilize joint cryo neutron/x-ray crystallography techniques to better understand the importance of the 2'-hydroxyl group in RNA's expanded three-dimensional structure compared to DNA....
- The National Science Foundation (NSF) awarded a $349,281 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of Texas at Austin and the University of Wisconsin, Madison. The grant, awarded on May 1, 2025, supports the collaborative development of a new polarizable 3D-RISM implicit solvent model to enable efficient and accurate computer simulations of RNA molecules. This new model aims to accurately represent the behavior of water molecules around...
- This federal Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) provides $699,999 to researchers at Indiana University School of Medicine to develop computational methods for accurately predicting how chemical modifications to RNA molecules affect their binding and interactions with regulatory proteins. The goal is to advance a physics-based molecular modeling technique called μ-dynamics to model the free energies...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) in the amount of $800,000.00 aims to dramatically expand the understanding of RNA modification enzymes (RMEs) - a class of proteins that chemically alter RNA molecules and influence their function, stability, and therapeutic potential. The project will systematically identify and assay over 750 RMEs from nearly 100 microbial organisms to establish foundational knowledge and resources to...
The National Science Foundation (NSF) Division of Chemistry awarded a $460,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to Drs. Harish Vashisth from the University of New Hampshire and Esteban A Orellana Vinueza from Dartmouth College. The 3-year grant, effective September 1, 2025, supports collaborative research to study how chemical modifications to transfer RNA (tRNA) bases affect the structure, folding, and dynamics of tRNA isodecoders, which are involved in protein biosynthesis. The researchers will apply a combination of experimental techniques, such as spectroscopic methods, CRISPR technology, translation assays, and proteomics, as well as computational methods like molecular dynamics simulations, to enhance the understanding of these modifications and their potential roles as therapeutic targets and diagnostic biomarkers. The project also incorporates outreach activities to visually teach spatial thinking skills about RNA structure and function to STEM learners, with the goal of increasing the national talent pool for the emerging field of RNA-based chemical tools and technologies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $460.0k | 8/20/25 |