Project Grant 2515735
- This $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will support research into the structural biology of RNA and RNA-protein interactions through May 2024. Funded under the Biological Sciences program (CFDA 47.074), this award to Vanderbilt University will utilize joint cryo neutron/x-ray crystallography techniques to better understand the importance of the 2'-hydroxyl group in RNA's expanded three-dimensional structure compared to DNA....
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- The National Science Foundation (NSF) Division of Chemistry awarded a $460,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to Drs. Harish Vashisth from the University of New Hampshire and Esteban A Orellana Vinueza from Dartmouth College. The 3-year grant, effective September 1, 2025, supports collaborative research to study how chemical modifications to transfer RNA (tRNA) bases affect the structure, folding, and dynamics of tRNA isodecoders, which are...
- This National Science Foundation Project Grant of $536,946 will support research at the University of California, San Diego from September 2022 through August 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund the development of rigorous scientific theories and powerful computational tools to model biomolecular interactions. Researchers will design advanced numerical methods to simulate drug and protein binding/unbinding kinetics, incorporating molecular...
- The National Science Foundation (NSF) awarded a $349,281 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of Texas at Austin and the University of Wisconsin, Madison. The grant, awarded on May 1, 2025, supports the collaborative development of a new polarizable 3D-RISM implicit solvent model to enable efficient and accurate computer simulations of RNA molecules. This new model aims to accurately represent the behavior of water molecules around...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $750,000 Project Grant titled "TRANSITIONS: EVOLVING OUR UNDERSTANDING OF DYNAMIC RNA FOLDING AND FUNCTION" to Northwestern University under the Biological Sciences grant program (CFDA 47.074). The objective of this 3-year award is to uncover fundamental principles linking RNA sequence to dynamic RNA folding processes and function in biological systems. The research aims to enhance the...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $414,164 Project Grant under the Biological Sciences CFDA program to the University of Illinois at Chicago. This 3-year grant, awarded on August 15, 2023, will support research to study how enzymes in intermediary metabolism interact with and bind to RNA molecules. The project aims to gain a greater understanding of these protein-RNA interactions and their effects on regulating cellular activities,...
- The University of Massachusetts at Amherst has been awarded a $536,802 Project Grant from the National Science Foundation's Mathematical and Physical Sciences Program (CFDA 47.049) to study the driving forces and molecular mechanisms behind RNA phase transitions. The principal investigator, Dr. Jianhan Chen, will develop a new coarse-grained molecular modeling framework called ICONRNA to efficiently simulate the spontaneous phase separation of flexible RNAs and heterotypic protein/RNA complexes....
- The Project Grant award, valued at $384,999 and provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), supports a research project conducted by The Leland Stanford Junior University (Stanford University). The project aims to address significant challenges in understanding RNA structure and its critical biological roles through a three-pronged approach: Developing computational tools, including an RNA sequence database (RNAMASS) and a novel...
- The National Science Foundation (NSF) awarded a $1,199,997 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Colorado-Denver. The grant will fund research to improve understanding of the mechanisms underlying messenger RNA (mRNA) localization and translation, and develop machine learning models to better predict protein production from mRNA. The project will apply recent advancements in RNA sequencing technology to study how factors like tRNA abundance and...
This federal Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) provides $699,999 to researchers at Indiana University School of Medicine to develop computational methods for accurately predicting how chemical modifications to RNA molecules affect their binding and interactions with regulatory proteins. The goal is to advance a physics-based molecular modeling technique called μ-dynamics to model the free energies of RNA-protein interactions, including the effects of over 170 known RNA base modifications. This will provide new insights into the biological function of RNA modifications relevant to biotechnology. In parallel, the project will create a summer program to engage junior trainees in literature about RNA modifications as an entry into STEM careers. The award period runs from September 1, 2025 through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $700.0k | 8/26/25 |