Project Grant 2516941

Award Date 6/1/25
Completion Date 5/31/28
Dollars Obligated $537K
Federal Grant Program
47.049
Assistance Type
Project Grant
Place of Performance
Amherst, MA 01003, USA
Similar Awards
This $750,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of a novel platform to enable rapid and robust identification of functional RNA molecules directly within mammalian cellular environments. The research aims to solve the challenge of RNA structure sensitivity to local environments that has hindered progress in the field of functional RNA discovery. The project will deliver a customized...
The National Science Foundation (NSF) Division of Chemistry awarded a $1,500,000 Project Grant to Stanford University under the Mathematical and Physical Sciences (MPS) program (CFDA 47.049). The grant, awarded on March 1, 2024, supports a 3-year research project titled "Evaluating and Advancing Cryo-EM for RNA Conformational Ensembles." The project aims to: (1) design, model, and experimentally probe RNA systems with discrete conformational states, and (2) characterize and challenge...
This Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049) provides $378,025 to support the development of a new polarizable implicit solvent model for efficient and accurate modeling of RNA structure and function. The principal investigators, Xuhui Huang of the University of Wisconsin, Madison and Pengyu Ren of the University of Texas, Austin, will derive a new form of the...
The National Science Foundation (NSF) Division of Chemistry awarded a $500,000 Project Grant titled "TOPICS IN PROTEIN AND RNA FOLDING AND DYNAMICS" to the University of Texas at Austin under the Mathematical and Physical Sciences program (CFDA 47.049). This 4-year grant will support Professor Devarajan Thirumalai's research on the computational modeling of protein and RNA interactions and dynamics. Key focus areas include developing new methods to simulate intrinsically disordered...
This National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) project grant award of $1,500,000 supports research by Dr. Tamar Schlick of New York University and Dr. Alain Laederach of the University of North Carolina at Chapel Hill. The project aims to develop advanced computational tools to predict and control how viral protein synthesis is affected by programmed ribosomal frameshifting (PRF) - the mechanism by which viruses and human cells modify gene expression. Key...
This federal Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) totaling $349,281 supports the development of a new polarizable implicit solvent model called Polarizable-3DRISM (P3DRISM) to enable efficient and accurate molecular dynamics simulations of RNA. The principal investigators, Xuhui Huang of the University of Wisconsin, Madison and Pengyu Ren of the University of Texas, Austin, will derive a new 3DRISM equation that...
This National Science Foundation Project Grant of $536,946 will support research at the University of California, San Diego from September 2022 through August 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund the development of rigorous scientific theories and powerful computational tools to model biomolecular interactions. Researchers will design advanced numerical methods to simulate drug and protein binding/unbinding kinetics, incorporating molecular...
This $324,118 National Science Foundation project grant supports research to decipher RNA-based regulatory logic through interpretable machine learning models. Funded under the Mathematical and Physical Sciences program (CFDA 47.049), the three-year award to New York University will develop and apply interpretable neural networks to massive parallel reporter assay datasets. Specifically, the models aim to elucidate the splicing code that determines exon skipping and the 5'UTR code regulating...
This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $522,131.00 to New York University (NYU) from August 1, 2023 to July 31, 2026. The funded research aims to understand the relationship between RNA sequence features and splicing outcomes, as well as the role that nuclear speckles play in RNA splicing decisions. The project will leverage high-throughput assays and interpretable machine learning to identify sequence-encoded...
This $299,999 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) will support research exploring the RNA world and RNA-peptide world hypotheses using a novel dynamic combinatorial chemistry system at the University of Houston, a minority-serving institution. The two-year project beginning August 1, 2022 aims to advance understanding of the role of RNA and peptides in the origins of life. Investigators will employ a system using benzonuclease to cleave...

This Project Grant award, provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049), supports research by Dr. Jianhan Chen of the University of Massachusetts at Amherst to develop a new computational framework for modeling the dynamic structure and phase separation of RNA molecules.

The $536,802 award, spanning June 2025 to May 2028, will fund the development of the ICONRNA coarse-grained model to efficiently simulate the spontaneous phase transitions of flexible RNA and heterotypic protein/RNA complexes. The research aims to uncover the molecular mechanisms governing the temperature and magnesium ion dependence of RNA phase separation, which is crucial for understanding biomolecular condensates in cellular functions. The project will also integrate the developed computational models into educational and outreach activities to train students and broaden participation in STEM. No subawards are planned under this grant.

Generated 6/17/25, 3:30 AM