Project Grant 2515932
- This $750,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of a novel platform to enable rapid and robust identification of functional RNA molecules directly within mammalian cellular environments. The research aims to solve the challenge of RNA structure sensitivity to local environments that has hindered progress in the field of functional RNA discovery. The project will deliver a customized...
- This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded a $1,050,000 Project Grant to Princeton University to deepen the understanding of chemical modifications on ribonucleic acid (RNA) and their role in biological processes. The 3-year project, titled "Illuminating the Dihydrouridine Epitranscriptome," aims to characterize the RNA modification dihydrouridine (D) and its writer enzymes, as well as elucidate their biological function...
- This Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences provides $300,000 to the University of California, San Diego for research titled "EAGER: DEVELOPING A HIGHLY SELECTIVE, ORTHOGONAL, ENZYMATIC RNA LABELING TECHNOLOGY VIA DIRECTED EVOLUTION OF AN RNA TRANSGLYCOSYLASE." The period of performance is from August 15, 2021 to July 31, 2023. The funding supports research under the NSF's Biological Sciences program (CFDA 47.074). The goal...
- This $1,555,035 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will fund research into the discovery of novel functional RNA classes through computational integration of massively-parallel RBP binding and structure data. The award was made under the Biological Sciences federal grant program (CFDA 47.074) to support basic biological research strengthening the nation's scientific enterprise. The California Institute of Technology will use the...
- This $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will support research into the structural biology of RNA and RNA-protein interactions through May 2024. Funded under the Biological Sciences program (CFDA 47.074), this award to Vanderbilt University will utilize joint cryo neutron/x-ray crystallography techniques to better understand the importance of the 2'-hydroxyl group in RNA's expanded three-dimensional structure compared to DNA....
- This federal Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) provides $699,999 to researchers at Indiana University School of Medicine to develop computational methods for accurately predicting how chemical modifications to RNA molecules affect their binding and interactions with regulatory proteins. The goal is to advance a physics-based molecular modeling technique called μ-dynamics to model the free energies...
- This $700,000 Project Grant was awarded by the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program to the University of California, San Diego (UCSD) on August 1, 2025. The grant funds a 3-year research project to investigate how bacteria use RNA "switches" called riboswitches to regulate the import and export of metal ions, which are important for cellular function but can be toxic in excess. Specifically, the project aims to map the co-transcriptional...
- This three-year, five-hundred twenty-three thousand four-hundred sixty-one dollar project grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund research into RNA processing in trypanosome mitochondria. The grant was awarded to Seattle Children's Research Institute on April 1, 2022 and will be completed by March 31, 2025. The project aims to advance understanding of gene expression regulation in trypanosomes, single-celled parasites that alternate...
- This $3,000,000 project grant, awarded by the National Science Foundation (NSF) under the Engineering (CFDA 47.041) program, aims to solve the long-standing challenge of developing self-amplifying ribonucleic acid (SARNA) technologies. The project, led by Trustees of Boston University, a private non-profit research university, will: Synthesize a diverse library of modified nucleoside triphosphates (ModNTPs) and use them to produce modified SARNA with extended cellular half-life. Evaluate the...
This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) in the amount of $800,000.00 aims to dramatically expand the understanding of RNA modification enzymes (RMEs) - a class of proteins that chemically alter RNA molecules and influence their function, stability, and therapeutic potential. The project will systematically identify and assay over 750 RMEs from nearly 100 microbial organisms to establish foundational knowledge and resources to support new RNA-based tools and applications. The research team at the University of California, Santa Cruz will use innovative high-throughput screening methods combining recombinant protein expression, in vitro RNA modification assays, and advanced sequencing technologies to characterize enzyme activity across collections of 800 different tRNAs and libraries of hundreds of other small RNA substrates. The results will be integrated into an interactive database and enzyme library made freely available to the broader scientific community, fostering further research and educational opportunities.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $800.0k | 8/19/25 |