Project Grant 2515799
- This $750,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of a novel platform to enable rapid and robust identification of functional RNA molecules directly within mammalian cellular environments. The research aims to solve the challenge of RNA structure sensitivity to local environments that has hindered progress in the field of functional RNA discovery. The project will deliver a customized...
- This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...
- This $1,211,545 Project Grant award from the National Science Foundation (CFDA 47.074 - Biological Sciences) will support the development of advanced Prime Editing (PE) systems in rice, tomato, and poplar plants. Prime Editing is a novel and highly versatile CRISPR-based gene editing technology that enables precise genome modifications. The key objectives of this 3-year project are to optimize Prime Editor proteins to increase their activity and editing efficiency, improve pegRNA structure and...
- This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) in the amount of $800,000.00 aims to dramatically expand the understanding of RNA modification enzymes (RMEs) - a class of proteins that chemically alter RNA molecules and influence their function, stability, and therapeutic potential. The project will systematically identify and assay over 750 RMEs from nearly 100 microbial organisms to establish foundational knowledge and resources to...
- This $117,074 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports research at Lehigh University to develop biomaterial-guided CRISPR gene editing delivery systems. The key objectives are to: Determine how peptide-based nanoparticle formulation and properties impact CRISPR ribonucleoprotein (RNP) uptake, activity, and functionality. Investigate how material charge and porosity control the temporal action of CRISPR...
- This Project Grant, awarded by the National Science Foundation's Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), provides $583,025 to Professors Shiyue Fang and Yinan Yuan of Michigan Technological University to develop new chemical technologies for the synthesis of long oligonucleotides (DNA and RNA segments). The research aims to overcome limitations of current biological methods and enable cost-effective production of long oligonucleotides essential for applications in...
- This federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049), supports collaborative research by professors Eriks Rozners of SUNY at Binghamton and James A. Mackay of Elizabethtown College. The $465,000 grant, awarded on August 15, 2024, focuses on developing new peptide nucleic acid (PNA) nucleobases capable of sequence-selective recognition of non-coding RNA. The research aims to uncover new methods for molecular...
- This federal Project Grant award, valued at $287,488 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a multi-year research initiative to deeply understand how proteins occupy conformational ensembles to enable biological functions. The overall goal is to develop strategies to computationally design new, functional protein ensembles from scratch, with a focus on engineering protein...
- This $360,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research by professors Eriks Rozners of SUNY at Binghamton and James A. Mackay of Elizabethtown College. The project aims to develop new peptide nucleic acid (PNA) molecules capable of selectively recognizing and binding to double-stranded non-coding RNA. This research addresses an important challenge in RNA biochemistry and could enable...
This $500,000 Project Grant award, funded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049), supports Drs. Chaolin Zhang and Harris H. Wang of Columbia University in developing engineered proteins that can precisely edit and control the expression of RNA sequences in human cells. The researchers will adapt pentatricopeptide repeat (PPR) proteins from plants to create a versatile platform for programmable RNA targeting, with the goal of overcoming limitations of current RNA-editing technologies. The project will evaluate the binding specificity, efficiency, and versatility of the engineered PPR proteins and compare them to existing methods like CRISPR and RNA interference. In parallel, the project will include public outreach and educational workshops on RNA biology and biotechnology. This research could lead to powerful new RNA-based tools with broad applications in biotechnology, agriculture, and medicine, while also promoting public understanding of cutting-edge biological science.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $500.0k | 8/26/25 |