Project Grant 2452305

Award Date 6/1/25
Completion Date 5/31/28
Dollars Obligated $583K
Federal Grant Program
47.049
Assistance Type
Project Grant
Place of Performance
Houghton, MI, USA
Similar Awards
This federal Project Grant award, valued at $444,262 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports the development of innovative reagents and methods for synthesizing oligophosphate constructs. The key products and services to be delivered include: New methods and reagents for synthesizing oligophosphate chains of increasing length, including pentaphosphate, hexaphosphate, and...
This $658,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) funds research by Professor Hsin-Chih Yeh and Professor Devleena Samanta at the University of Texas at Austin. The goal is to develop new types of functional nucleic acid molecules that can be used as sensitive, selective, and adaptable sensors for diverse chemical and biological applications. The research aims to discover catalytic functional nucleic acids that...
The National Science Foundation Division of Chemistry awarded Northeastern University a $500,000 Project Grant under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to support the de novo asymmetric synthesis of natural and unnatural oligosaccharide motifs from August 15, 2021 through July 31, 2024. This funding will advance progress in the mathematical and physical sciences by enabling Northeastern University researchers to increase the store of scientific knowledge...
This $300,000 Project Grant award from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) supports the development and experimental validation of computational tools for designing DNA nanostructures and molecular systems. The primary goal is to create novel multiscale modeling frameworks that can harness the predictive power of low-level molecular dynamics models while providing the ease of simulation offered by higher-level models. The project will also further...
This $159,819 federal Project Grant award, provided by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), will support research by Dr. John Chaput at the University of California, Irvine to investigate the mechanism of DNA synthesis using advanced time-resolved X-ray crystallography. The goal is to capture "snapshot" images that can be assembled into an animated model showing the precise...
This $575,000 project grant awarded by the National Science Foundation's (NSF) Division of Chemistry (CFDA 47.049 - Mathematical and Physical Sciences) will support a research effort led by Professor George O'Doherty at Northeastern University to develop novel synthetic methods for the asymmetric synthesis of oligosaccharide structures. The project aims to enable the efficient, de novo construction of both natural and unnatural oligosaccharide motifs, which have important applications in biology...
This $236,662 National Science Foundation award through the Mathematical and Physical Sciences program (CFDA 47.049) funds research at Emory University to develop novel biomimetic materials capable of simultaneously encoding both nucleic acid and protein information codes to control assembly and function. Specifically, the award supports exploration of "bilingual biopolymers" using peptide nucleic acid as a scaffold to direct structure based on both peptide and nucleic acid...
The National Science Foundation Division of Chemistry awarded a $480,002 project grant to the Regents of the University of Minnesota for the project "DNA-TEMPLATED SUPRAMOLECULAR SYNTHESIS OF WIREFRAME POLYMERS" under the Mathematical and Physical Sciences program (CFDA 47.049). The three-year project beginning August 1, 2021 will support the development of DNA-templated synthetic methods to create wireframe polymers with targeted shapes and properties. The Mathematical and Physical...
This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) is providing $275,000 to Dinya DNA Inc. to support the commercial development of a novel DNA synthesis technology. The key products or services being delivered include: Developing new methods to ensure higher fidelity DNA precursors, which are the building blocks for DNA synthesis Reducing synthesis costs by streamlining the DNA synthesis reactions...
This National Science Foundation (NSF) Project Grant, awarded under the Mathematical and Physical Sciences (CFDA 47.049) program, provides $233,333 to The Ohio State University to develop and implement multifunctional DNA-based nanoscale devices. The goal is to detect genetic activity and control gene expression, particularly related to cell state and differentiated functions. The devices will enable mechanical control of gene regulation and provide insights into how chromatin structure and...

This National Science Foundation (NSF) Division of Chemistry "Chemical Synthesis of Long Oligonucleotides" Project Grant, awarded under the CFDA 47.049 Mathematical and Physical Sciences program, supports research by Professors Shiyue Fang and Yinan Yuan of Michigan Technological University to develop new chemical technologies for the synthesis of long oligodeoxyribonucleotides (ODNs) and oligoribonucleotides (ORNs). The $583,025 award aims to extend the capabilities of chemical synthesis to produce ODNs beyond 2,000 base pairs and ORNs up to 200 base pairs, addressing limitations of current biological synthesis methods. The project will involve a multidisciplinary team acquiring technical skills in areas like organic synthesis, surface chemistry, DNA/RNA sequencing, and characterization. No sub-awards are planned under this grant, which runs from June 1, 2025 to May 31, 2028.

Generated 6/17/25, 3:23 AM