Project Grant 2514387
- The National Science Foundation (NSF) awarded a $353,843 Project Grant under CFDA Program 47.041 (Engineering) to the University of Washington to develop a unique biosensing system in E. coli bacteria to recognize extracellular cancer antigens and respond with a toxic, immunostimulatory payload. This 3-year project from March 2025 to February 2028 aims to create programmable and dynamically-responsive bacterial therapeutics as a low-cost alternative to engineered human T cell therapies for...
- The National Science Foundation awarded a $398,968 project grant to Texas A&M Engineering Experiment Station (doing business as Tees) to support research titled "Computational and Experimental Design of Novel Peptide Nanocarriers for Cancer Drugs" from August 1, 2021 through July 31, 2025. Under the grant, Tees will conduct research to computationally and experimentally design new peptide-based nanocarriers to deliver cancer drugs. The work aims to improve drug delivery for...
- This $149,403 federal Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) to North Carolina Agricultural and Technical State University (NC A&T) aims to develop a "theragnostic" (therapeutic and diagnostic) system for inflammatory bowel diseases (IBD). The project integrates data science, synthetic biology, and additive manufacturing to: 1) model the complex interactions between host, microbial, and environmental factors underlying...
- This Project Grant from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems provides $474,861 to North Carolina State University under the Engineering program (CFDA 47.041) from January 15, 2023 to December 31, 2027. The award will fund research to develop strategies for improving the ability of genetically engineered probiotic yeast to reside long-term in the gut, with the goal of enabling in situ biomanufacturing of therapeutic agents to...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded a $550,000 project grant to the University of California, Berkeley to develop a miniaturized, sensitive, and user-friendly biosensing platform for rapid bacterial infection diagnostics. The award, effective April 1, 2025 through March 31, 2030, aims to create an integrated circuit (IC) chip and microfluidic system that combines physics-based dielectric spectroscopy and biochemistry-based magnetic nanoparticle...
- This federal Project Grant award of $339,999, provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research to study the spatiotemporal dynamics of intercellular signaling in engineered multicellular bacterial systems. The research aims to develop novel mathematical modeling techniques that can better predict the behavior of spatially extended synthetic bacterial populations, which have potential applications...
- The National Science Foundation (NSF) awarded a $401,490 Project Grant under the Engineering program (CFDA 47.041) to the University of Massachusetts (UMass) to develop a modular toolset for imaging cellular metabolites using fluorogenic RNA riboswitches. The project aims to engineer fluorescent probes that can selectively detect and measure key metabolites, such as sugars and fatty acids, within living cells in real-time. This novel approach will enhance research in human health, nutrition,...
- The National Science Foundation (NSF) awarded a $300,000 Project Grant to the University of Chicago for the "BRING-SYNBIO: DYNAMIC COOPERATIVE BINDERS FOR ENDOGENOUSLY GATED CELLULAR CONTROL" project under the NSF Engineering program (CFDA 47.041). This project aims to develop a new class of intrinsically disordered proteins that can directly sense environmental cues and trigger rapid, targeted changes in cellular responses, such as directing tumor cells to break apart and die. The...
- This $500,000 Project Grant was awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) to William Marsh Rice University in Houston, Texas. The funding will support research to increase the secretion capacity of therapeutic cells, enabling them to produce higher levels of proteins to aid in disease treatment. The project aims to understand the mechanisms driving high antibody production in plasma cells and apply these insights to modify existing therapy-grade cells....
- This National Science Foundation (NSF) Project Grant, awarded under the Computer and Information Science and Engineering (CISE) program (CFDA 47.070), provides $168,690 to the Florida Institute of Technology Inc. (Florida TECH) to develop a theragnostic (therapeutic + diagnostic) system for inflammatory bowel diseases (IBD). The project aims to model the complex interplay of host, microbial, and environmental factors that trigger IBD using data science, and then leverage synthetic biology and...
The National Science Foundation (NSF) awarded a $300,000 Project Grant under the CFDA 47.041 Engineering program to the Texas A&M Engineering Experiment Station (Tees) in College Station, TX. The 4-year grant, titled "BRING-SYNBIO: Erythritol-Driven and Spatiotemporal-Controlled Probiotics for Precise Delivery of Checkpoint-Blocking Nanobodies", aims to develop a probiotic strain of E. coli Nissle 1917 engineered with genetic circuits to sense tumor signals, synthesize anti-tumor nanobodies, and release them in response to the artificial sweetener erythritol. This innovative approach seeks to precisely target and treat solid tumors, which are difficult to treat with conventional therapies. The project includes educational and outreach components to provide hands-on research opportunities for students and trainees.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $300.0k | 7/24/25 |