Project Grant 2306739
- This $202,728 federal Project Grant awarded by the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program funds a collaborative research project to develop a theragnostic (therapeutic and diagnostic) system for inflammatory bowel diseases (IBD). The project aims to integrate data science, synthetic biology, and additive manufacturing to model the complex interplay of host, microbial, and environmental factors in IBD, and develop an engineered...
- This National Science Foundation (NSF) Project Grant, awarded under the Computer and Information Science and Engineering (CISE) program (CFDA 47.070), provides $168,690 to the Florida Institute of Technology Inc. (Florida TECH) to develop a theragnostic (therapeutic + diagnostic) system for inflammatory bowel diseases (IBD). The project aims to model the complex interplay of host, microbial, and environmental factors that trigger IBD using data science, and then leverage synthetic biology and...
- This $552,957 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) aims to develop an in-vitro microfluidic platform to study the interaction between gut microbiota and brain tissue models, particularly in the context of neurodegenerative disorders. The project, awarded to Iowa State University of Science and Technology, will integrate research and education to train undergraduate and graduate students in interdisciplinary studies of the...
- This Project Grant from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems provides $474,861 to North Carolina State University under the Engineering program (CFDA 47.041) from January 15, 2023 to December 31, 2027. The award will fund research to develop strategies for improving the ability of genetically engineered probiotic yeast to reside long-term in the gut, with the goal of enabling in situ biomanufacturing of therapeutic agents to...
- This Project Grant award of $104,917 from the National Science Foundation's (CFDA 47.074) Biological Sciences program will support a team of undergraduate students at the University of Virginia in developing a low-cost treatment for exocrine pancreatic insufficiency. The students will design and build a probiotic that secretes synthetic pancreatic enzymes, with the goal of providing this treatment solution for the International Genetically Engineered Machines (iGEM) competition in synthetic...
- This federal Project Grant award of $790,359, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to develop a targeted probiotic yeast therapeutic for treating inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. The research project aims to design, characterize, and optimize a fibronectin-targeting, nanobody...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $305,000 to Foli Bio Inc. supports the development of a high-throughput fecal exfoliome analyzing platform for use in clinical drug development. The goal is to enable pharmaceutical companies to better evaluate and tailor treatments for inflammatory bowel disease (IBD), which affects over 3 million people in the United States. The platform is designed to provide a more detailed,...
- The National Science Foundation (NSF) awarded a $353,843 Project Grant under CFDA Program 47.041 (Engineering) to the University of Washington to develop a unique biosensing system in E. coli bacteria to recognize extracellular cancer antigens and respond with a toxic, immunostimulatory payload. This 3-year project from March 2025 to February 2028 aims to create programmable and dynamically-responsive bacterial therapeutics as a low-cost alternative to engineered human T cell therapies for...
- This federal Project Grant award of $339,999, provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research to study the spatiotemporal dynamics of intercellular signaling in engineered multicellular bacterial systems. The research aims to develop novel mathematical modeling techniques that can better predict the behavior of spatially extended synthetic bacterial populations, which have potential applications...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded North Carolina State University a $510,838 Project Grant under the Engineering (47.041) federal grant program. The three-year award will support the BIO-MAPS: BIOMOLECULAR-ARRAY PATTERNS FOR PRECISION DIFFERENTIATION OF INTESTINAL STEM CELLS project from July 2021 through June 2024. The project aims to develop biomolecular array techniques to precisely differentiate intestinal...
This $149,403 federal Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) to North Carolina Agricultural and Technical State University (NC A&T) aims to develop a "theragnostic" (therapeutic and diagnostic) system for inflammatory bowel diseases (IBD). The project integrates data science, synthetic biology, and additive manufacturing to: 1) model the complex interactions between host, microbial, and environmental factors underlying IBD, 2) engineer bacteria to detect IBD biomarkers and express anti-inflammatory agents, and 3) design a 3D-printed smart pill to securely deliver the engineered bacteria to the gastrointestinal tract. This innovative theragnostic system, if successful, could improve diagnosis and treatment of IBD, which affects millions globally. The project also includes educational components to engage underrepresented minority students in STEM fields from middle school through graduate training.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $149.4k | 9/7/23 |