Project Grant 2504133
- This $360,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research by professors Eriks Rozners of SUNY at Binghamton and James A. Mackay of Elizabethtown College. The project aims to develop new peptide nucleic acid (PNA) molecules capable of selectively recognizing and binding to double-stranded non-coding RNA. This research addresses an important challenge in RNA biochemistry and could enable...
- This $236,662 National Science Foundation award through the Mathematical and Physical Sciences program (CFDA 47.049) funds research at Emory University to develop novel biomimetic materials capable of simultaneously encoding both nucleic acid and protein information codes to control assembly and function. Specifically, the award supports exploration of "bilingual biopolymers" using peptide nucleic acid as a scaffold to direct structure based on both peptide and nucleic acid...
- This federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049), supports collaborative research by professors Eriks Rozners of SUNY at Binghamton and James A. Mackay of Elizabethtown College. The $465,000 grant, awarded on August 15, 2024, focuses on developing new peptide nucleic acid (PNA) nucleobases capable of sequence-selective recognition of non-coding RNA. The research aims to uncover new methods for molecular...
- This Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program provides $576,411.00 in funding to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to conduct research into how enzymes regulate the communication between cells through physical "bridges" that can be severed. The project aims to uncover the mechanisms of how these enzymes, known as ADAM proteases, recognize and cleave these...
- This Project Grant award for $140,390 was provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The award supports research to develop porous peptide frameworks inspired by the modular architecture of proteins. The research aims to engineer these frameworks by appending peptides with aromatic π-stackers to guide the predictable self-assembly of the peptides into sophisticated porous materials. If successful, these...
- This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) will support research to investigate the roles of amino acid isomerization, a chemical modification that affects the structure and function of cell-cell signaling peptides. The $681,070 award to the Board of Regents of the University of Nebraska, which operates as the University of Nebraska, aims to provide critical insights into how living systems alter their cellular communication...
- This $480,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports the development of novel approaches for assembling three-dimensional protein biomaterials. The primary goal is to create "coordinated protein frameworks" (CPFs) - extended protein lattices with defined geometries and tunable distances between the assembled proteins. This work leverages non-canonical amino acids to precisely control the...
- This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
- This Project Grant award from the National Science Foundation's Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports a collaborative research effort led by Emory University and the University of Illinois Chicago to design and develop peptide-based filamentous nanomaterials. The $300,000 award, effective from August 1, 2024 to July 31, 2027, will leverage computational methods to systematically explore the energetics and structural designability of...
- This Project Grant award from the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program provides $451,460 to Emory University to conduct collaborative research on the computational design of peptide-based filamentous nanomaterials. The project, led by researchers from Emory University and the University of Illinois Chicago, aims to develop a general scientific approach to computation-guided design of...
This Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049), supports biophysical research on peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme critical for neuropeptide production in humans and other organisms. The $689,250 award, with a performance period from September 1, 2025 to August 31, 2028, enables researchers at the University of South Florida, Boston University, and the Foundation for Molecular Evolution to investigate how full-length PAM binds to and modifies neuropeptide precursors. The project will provide new insights into PAM's catalytic mechanism and inter-domain communication, as well as the structural basis of PAM's interaction with the precursor to atrial natriuretic peptide. The research findings will be disseminated through a series of educational outreach events at the Museum of Science and Industry, aimed at improving scientific literacy and inspiring students to pursue research in neuroscience and medicine.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $689.3k | 8/27/25 |