Project Grant 2516669
- This Project Grant award for $140,390 was provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The award supports research to develop porous peptide frameworks inspired by the modular architecture of proteins. The research aims to engineer these frameworks by appending peptides with aromatic π-stackers to guide the predictable self-assembly of the peptides into sophisticated porous materials. If successful, these...
- This $200,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research effort led by New York University (NYU) School of Medicine. The project aims to enhance the design of fluorinated protein fibers and hydrogels for medical applications. Key objectives include: 1) generating coiled-coil fluorinated fibers for controlled drug delivery, 2) developing temperature-responsive fluorinated hydrogels,...
- This $500,000 federal Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) supports research at Northwestern University to develop de novo designed proteins as mechano-responsive junctions in protein-polymer networks. The key objectives are to: (i) synthesize and computationally simulate de novo designed proteins and their respective protein-polymer networks, and (ii) develop techniques for mechanical characterization...
- This Project Grant award of $1,500,000 from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports research to elucidate the design principles for de novo designed proteins as mechano-responsive junctions in protein-polymer networks. The key products and services to be delivered include: (1) Development of de novo designed proteins that can be readily transformed into junctions within polymer networks. (2) Investigation of the use of de novo...
- This $232,771 Project Grant, awarded on September 15, 2025, was provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program. The grant aims to develop computational mathematical tools to better understand protein structures and interactions, even across a wide range of mutations. This interdisciplinary research combines mathematical modeling, machine learning, and biology to analyze the complex shapes of proteins, with the goal of enabling...
- This Project Grant award, provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) program, supports research on a new class of materials called protein-like polymers (PLPs). The $170,954 award funds a collaborative research effort to study how these PLP materials can mimic the structure and function of proteins, enabling them to interact with and penetrate biological membranes and cells. The goal is to elucidate the mechanisms by which...
- This $1,500,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program will support research at Northwestern University to develop innovative protein-based biomaterials. The research aims to (1) engineer mussel foot proteins with superior underwater adhesive properties compared to wild-type sequences, and (2) create resilin-inspired bioelastomers with high strength while retaining natural mechanical resilience. The proposed...
- This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049), in the amount of $642,000, will fund research at Northwestern University to develop novel hybrid protein-DNA supramolecular structures. The key objectives are to: (1) design generalizable strategies for site-specific DNA functionalization to control proteins in 1D arrays; (2) create dynamic, DNA-driven 2D protein lattices; and (3) utilize DNA interactions to facilitate...
- This $236,662 National Science Foundation award through the Mathematical and Physical Sciences program (CFDA 47.049) funds research at Emory University to develop novel biomimetic materials capable of simultaneously encoding both nucleic acid and protein information codes to control assembly and function. Specifically, the award supports exploration of "bilingual biopolymers" using peptide nucleic acid as a scaffold to direct structure based on both peptide and nucleic acid...
- The National Science Foundation (NSF) Division of Materials Research awarded a $499,999 Project Grant to Arizona State University (ASU) under the Mathematical and Physical Sciences program (CFDA 47.049). The three-year grant project aims to: 1) create 3D DNA crystal scaffolds to host and determine the structure of RNA aptamers; 2) attach and immobilize functional proteins like enzymes within the crystal lattices to develop catalytic materials; and 3) develop sub-100 nm DNA nano-crystals to...
This $480,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports the development of novel approaches for assembling three-dimensional protein biomaterials. The primary goal is to create "coordinated protein frameworks" (CPFs) - extended protein lattices with defined geometries and tunable distances between the assembled proteins. This work leverages non-canonical amino acids to precisely control the geometric relationships and distances within the protein lattice, enabling the creation of new classes of functional biomaterials. The award, which runs from September 1, 2025 to August 31, 2028, will fund research at Arizona State University to advance this biomaterials design capability, with potential impacts in fields such as biotechnology, bioremediation, drug delivery, and medical technologies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $480.0k | 8/18/25 |