This five-year, $275,000 Project Grant from the National Science Foundation's Integrative Activities program (CFDA 47.083) will support the development of a single walled carbon nanotube sensor system to simultaneously quantify hydrogen peroxide and nitric oxide concentrations. The grantee, the University of Nebraska, will develop a sterile platform to identify the extracellular concentration profiles of these reactive oxygen and nitrogen species associated with breast, skin, and lymphocyte...
The National Science Foundation (NSF) Division of Chemistry awarded a $249,793 Project Grant to the University of California, Santa Barbara (UCSB) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The grant supports the development of new ruthenium-based chemical tools to study the biological roles of the gasotransmitter hydrogen sulfide (H2S) in eukaryotic cells. Specifically, the research team at UCSB aims to create hydrogen sulfide-releasing compounds activated...
This $432,740 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) to the Cal Poly Corporation supports the development of a new class of paper-based chronometric biosensors. The objective is to create quantitative point-of-care diagnostic tools that can detect a range of biological analytes, including disease markers, environmental contaminants, and security threats, using time as the sensing signal. The novel biosensors will leverage polymer...
The National Science Foundation (NSF) Division of Chemistry awarded a $420,000 Project Grant to the University of Utah from August 1, 2023 to July 31, 2026 under the Mathematical and Physical Sciences program (CFDA 47.049). The funding supports the development of a novel optical biosensor capable of detecting and quantifying a wide range of biological molecules, including biomarkers found in bodily fluids. The project leverages second harmonic generation (SHG) and optical heterodyning techniques...
This $587,497 Project Grant award, funded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049), supports the development of new fluorescent dyes and their applications in biology and materials science. Professors Maria da Graça H. Vicente of Louisiana State University and Petia Bobadova of Appalachian State University will collaborate on this 3-year project to design, synthesize, and investigate the properties of...
This $200,000 Project Grant award from the National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) program aims to enhance the design of fluorinated protein fibers and hydrogels for medical applications. The key objectives are to: 1) generate coiled-coil fluorinated fibers for controlled drug delivery, 2) develop fluorinated coiled-coil hydrogels responsive to temperature changes, and 3) assess the potential of these materials as magnetic resonance spectroscopy/imaging...
The University of California, San Diego received a $550,000 Project Grant award from the National Science Foundation Division of Materials Research to develop fractal plasmonic biomaterials for sensing and education applications. The grant, awarded under the Mathematical and Physical Sciences program (CFDA 47.049), will support research to understand the mechanism by which defined peptide sequences direct the hierarchical self-assembly of silver nanoparticles into complex fractal structures with...
This Project Grant award, valued at $300,000.00 and supported by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049), aims to enhance the design of fluorinated protein fibers and hydrogels for medical applications. The key objectives include: Generating coiled-coil fluorinated fibers for controlled drug delivery, Developing fluorinated coiled-coil hydrogels that change with temperature, and Assessing the potential of these fluorinated materials as 19F...
The National Science Foundation (NSF) awarded a $560,000 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of California, Santa Barbara (UCSB). The 3-year grant, effective September 1, 2024, will support research led by Prof. Thuc-Quyen Nguyen to develop a new class of sustainable, water-processable carbon-based semiconductors called conjugated polyelectrolytes (CPEs). The project aims to enhance the fundamental understanding of how CPE...
This Project Grant award for $145,598, provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program, supports the development of peptide-based, stimuli-responsive biomaterials for wound healing and drug delivery applications. The principal investigator at Baylor University will design three classes of self-healing, antimicrobial hydrogels that change stiffness in response to changes in redox state and pH. This research aims to generate...
This $139,543 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of extended lifetime peroxynitrite-responsive probes (XL-PRPs) - a novel class of biomaterials designed for long-term, non-invasive monitoring of oxidative stress biomarkers related to chronic diseases. The principal investigator at the University of California, Santa Barbara (UCSB) aims to achieve reversible peroxynitrite responsiveness, macromolecular structures for delayed tissue clearance, and near-infrared fluorescence for enhanced imaging depth. This work will establish the first reversible peroxynitrite probes responsive to biochemical scavengers in vivo, enabling localized, long-term monitoring of oxidative stress to improve chronic disease diagnosis and management. The project also includes outreach programs to introduce high school students to polymer chemistry, develop interactive biomaterials courses, and promote equitable career preparation in the chemical sciences.