Project Grant 2443848
- Federal Project Grant Award Summary The University of Texas Health Science Center at Houston received a $2.62 million project grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). Awarded on September 8, 2025, with a completion date of September 7, 2029, this five-year project focuses on advancing intestinal tissue engineering to address pediatric intestinal failure....
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a Project Grant of $2,557,146 to the University of Nevada, Reno (Board of Regents of the Nevada System of Higher Education) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 15, 2025, through September 14, 2029. The research project investigates novel regulatory targets for gastrointestinal hormones and neuropeptides in...
- This $193,274 National Science Foundation Engineering project grant funds research at New Mexico State University from February 2022 to January 2024 to advance understanding of particle dissolution mechanisms and develop techniques to actively control particle dissolution rates. The research will utilize high-fidelity modeling, precision experiments, and machine learning to identify the role of fluid shear flow in dissolving non-spherical particle systems. Researchers will study the coupled...
- This $502,203 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) funds research at the University of North Carolina at Greensboro to advance understanding of gastrointestinal tract variation in small mammals inhabiting seasonal environments in the Appalachian Mountains. Over three years, the university will conduct seasonal field collections of small mammals at three National Ecological Observatory Network sites. Researchers will generate a...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $719,638 to Cornell University to conduct fundamental research on the nanomechanics of bacterial adhesion and growth on healthy and diseased human gut mucus. The research aims to determine how differences in the molecular structures of healthy and diseased gut mucus impact bacterial adhesion and biofilm formation. The project will use computational modeling and simulations to obtain...
- The National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases awarded a $152,205 Project Grant to The Regents of the University of California San Francisco under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant funds research to investigate how vagal sensory neurons regulate autonomic responses to achieve metabolic homeostasis, and how downstream neuronal circuits in the nucleus tractus solitarius integrate...
- This National Science Foundation (NSF) Engineering program (CFDA 47.041) CAREER award, totaling $292,038 and awarded on May 1, 2025, funds fundamental research on the transport and collective behavior of microswimmers in porous media at the California Institute of Technology (Caltech) in Pasadena, California. The project delivers experimental techniques and mathematical models to understand how bacteria move and self-organize within confined porous environments such as tissue, gels, soils, and...
- NSF POSTDOCTORAL FELLOWSHIP IN BIOLOGY FY 2021: USING METACOMMUNITY THEORY TO ASSESS THE IMPACT OF MULTI-SPECIES INTERACTIONS ON GUT MICROBIAL ASSEMBLY This $138,000 Project Grant from the National Science Foundation Division of Environmental Biology will fund research from January 1, 2022 to December 31, 2023. The grant was awarded under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the nation's scientific enterprise...
- The National Science Foundation (NSF) awarded a $270,000 Postdoctoral Research Fellowship in Biology (PRFB) grant under the Biological Sciences (CFDA 47.074) program. The 3-year grant, which begins on March 1, 2026, will fund research to elucidate the chemical potential of the small intestinal microbiome. The project aims to characterize how individual small intestine microbes and microbial communities respond to host factors and protect against pathogens, with the goal of advancing basic...
- Engineering Research Initiation Grant Summary Kennesaw State University Research and Service Foundation received a $199,208 Engineering Research Initiation (ERI) Project Grant from the National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation (CFDA 47.041) awarded on June 15, 2025, with a completion date of May 31, 2027. The project delivers fundamental research and computational modeling services focused on multiscale electromechanical modeling of stomach...
CAREER:A MULTISCALE MECHANISTIC FRAMEWORK FOR THE HUMAN BODY'S ACTIVE REGULATION OF DIGESTION AND ABSORPTION THROUGH THE CONTROL OF MIXING AND TRANSPORT IN THE SMALL INTESTINE -THE DIGESTION AND ABSORPTION OF FOOD IN THE SMALL INTESTINE INVOLVE A COMPLEX ARRAY OF PROCESSES. THESE PROCESSES ENCOMPASS THE TRANSPORT OF FOOD PARTICLES ALONG THE INTESTINAL TRACT, THEIR MIXING WITH DIGESTIVE ENZYMES, AND THE MOVEMENT OF NUTRIENTS TO THE SURFACE OF THE INTESTINAL WALL. THESE PROCESSES ARE FACILITATED BY THE RHYTHMIC MOVEMENTS OF THE INTESTINAL WALL AND MICROSTRUCTURES ON ITS INNER SURFACE. THIS SUGGESTS THAT THE HUMAN BODY MAY REGULATE DIGESTION AND ABSORPTION IN THE SMALL INTESTINE BY CONTROLLING THESE MOVEMENTS. THIS PROJECT WILL UNCOVER THE MECHANISMS BY WHICH THE SMALL INTESTINE MIXES AND TRANSPORTS FOOD PARTICLES, ENZYMES, AND NUTRIENTS ACROSS DIFFERENT SCALES, ULTIMATELY REGULATING DIGESTION AND ABSORPTION. THE STUDY WILL EMPLOY ADVANCED NUMERICAL SIMULATIONS, THEORETICAL ANALYSIS, AND DATA ANALYSIS TECHNIQUES TO EXPLORE THE INTRICATE PROCESSES INVOLVED. THIS PROJECT COMPRISES HIGH-FIDELITY NUMERICAL SIMULATIONS OF MULTISCALE MECHANISMS, ADVANCED THEORETICAL ANALYSIS GROUNDED IN PHYSICS, AND DATA ANALYSIS TECHNIQUES LEVERAGING MACHINE LEARNING. THE PRIMARY OBJECTIVE IS TO ESTABLISH A MECHANISTIC FRAMEWORK FOR UNDERSTANDING HOW HUMAN PHYSIOLOGICAL SYSTEMS MANAGE DIGESTION AND ABSORPTION BY REGULATING THESE MIXING AND TRANSPORT PROCESSES IN THE SMALL INTESTINE. THIS WILL BE ACHIEVED THROUGH TWO SPECIFIC GOALS; 1) UNCOVER THE MECHANISMS OF MIXING, TRANSPORT, AND BREAKDOWN OF CHYME PARTICLES, ALONG WITH DISSOLVED ENZYMES AND NUTRIENTS IN INTESTINAL FLUIDS AND 2) IDENTIFY THE IMPACT OF MIXING AND TRANSPORT PROCESSES IN THE SMALL INTESTINE UNDER VARIOUS CONDITIONS ON FOOD DIGESTION, NUTRIENT ABSORPTION, AND ENERGY CONSUMPTION. THE GOAL IS TO CLARIFY THE REGULATORY MECHANISMS OF THE HUMAN PHYSIOLOGICAL SYSTEM THROUGH COMPARISON WITH IN VIVO INTESTINAL MOTILITY PATTERNS. THIS AWARD WILL ALSO ADVANCE MULTIDISCIPLINARY RESEARCH AND EDUCATION IN MULTIPHASE FLOWS AND WILL ENHANCE THE EDUCATION OF STUDENTS IN NEW MEXICO. THIS PROJECT IS JOINTLY FUNDED BY PARTICULATE AND MULTIPHASE PROGRAM AND THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $285.3k | 5/30/25 |