This Project Grant award from the National Science Foundation (NSF) Social, Behavioral, and Economic Sciences (SBE) program (CFDA 47.075) provides $193,699 to President and Fellows of Harvard College to conduct research on how biological sex is studied in laboratory models. The project aims to develop a clarifying account of research constructs for studying biological sex, in order to improve rigor, reproducibility, and precision in this area of research. Through case studies, interviews, and...
This $149,999 Project Grant award from the National Science Foundation's Integrative Activities (CFDA 47.083) program will support a collaborative research effort to model X-chromosome inactivation in human cells. The principal investigators from New York University, Harvard University, and the New Mexico Consortium will leverage expertise in molecular biology, genomics, computational biology, biophysics, and biomolecular modeling to investigate the complex genome organization and epigenetic...
This Project Grant from the National Science Foundation will fund $321,072 in research at the Reed Institute under the Biological Sciences federal grant program (CFDA 47.074) from March 2022 through February 2025. The research aims to investigate the evolutionary and biological basis of physical and behavioral traits that are sex-biased toward male or female expression across multiple levels of biological organization. Researchers will study global hormone levels, metabolic enzymes, hormone...
This $600,019 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research effort led by New York University (NYU) to investigate the structure and function of the X chromosome, with a focus on the process of X-chromosome inactivation. The research team, which also includes researchers from Harvard University and the New Mexico Consortium, will integrate high-resolution genomics data with advanced spatial modeling to...
The National Science Foundation, through its Integrative Activities program (CFDA 47.083), has awarded a $160,000 project grant to Iowa State University of Science and Technology (Iowa State University) to develop an innovative 3D cell culture platform that can model the transport of pharmaceutical agents across the placental barrier. The project aims to enable quantitative studies on a wide range of pharmaceuticals, understand their interactions, transport through the vasculature, and...
This $231,032 Project Grant awarded on February 1, 2024 by the National Science Foundation (NSF) Integrative Activities (IA) program (CFDA 47.083) supports research at Wichita State University to develop 3D computational models of live endothelial cell dynamics. The project will leverage expertise at the Allen Institute for Cell Science in Seattle to create machine learning algorithms that can predict 3D subcellular morphology of live endothelial cells from limited imaging data. This work aims...
This National Science Foundation (NSF) Project Grant under the Biological Sciences program (CFDA 47.074) provides $668,572 in funding to Northeastern University to conduct research on the molecular and biophysical mechanisms underlying contractile valve assembly and function. The research aims to characterize the inner structure and regulatory mechanisms of a donut-shaped contractile valve in the reproductive system of the nematode C. elegans, using advanced microscopy, genetic perturbations,...
This Project Grant from the National Science Foundation (NSF) Office of Integrative Activities provides $739,184 to Tulane University for collaborative research under the Integrative Activities federal grant program (CFDA 47.083). The research aims to design a sustainable agricultural production system through convergence research using a multi-scale ecosystems approach. Tulane will work with sub-awardees the University of North Carolina at Wilmington ($55,278) and Mesoamerican Development...
This $162,163 Project Grant award from the National Science Foundation's STEM Education (CFDA 47.076) program will fund a qualitative research project examining how undergraduate biology curricula represent sex and gender diversity, and the impact on transgender, non-binary, and gender non-conforming (TNG) students. The key goals of the project are to: 1) explore how sex and gender are currently portrayed in undergraduate biology content, 2) describe the impact this has on classroom climate...
This National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences project grant for $300,000 aims to engineer shape-morphing materials as cell sheet culturing substrates to develop human tissues with controllable shape, cellular composition, and morphology. The 3-year project, beginning on September 1, 2023, will use thermoresponsive hydrogels to enable cell sheet expulsion and explore how material characteristics impact stem cell fate. Additionally, the project seeks...