Project Grant 2321975
- Federal Grant Award Summary The University of Missouri System received a $165,787 Project Grant from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships program (CFDA 47.084), awarded October 1, 2025, with completion targeted for October 31, 2026. This Partnerships for Innovation Mid-Career Advancement (PFI-MCA) project delivers an innovative platform technology integrating three-dimensional cell culture, sensing, and imaging capabilities to model...
- This $550,000 Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development and validation of a non-invasive, multiplex blood test for the early detection of preeclampsia, a serious pregnancy complication. The project aims to advance the detection of vascular dysfunction, particularly preeclampsia, by optimizing a blood test that targets disease-inducing signaling proteins on the surface of...
- This National Science Foundation (NSF) Engineering (CFDA 47.041) Project Grant award to Worcester Polytechnic Institute (WPI) in the amount of $259,570 will develop 3D spheroid models using patient-derived trophoblast cells to investigate placental cell invasion and study preeclampsia, a pregnancy complication with high global maternal and infant mortality rates. The 2-year project will design culture conditions to maintain the spheroid models, engineer an extracellular matrix to mimic the...
- This $878,496 Project Grant award from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) supports a research project at the Morehouse School of Medicine (MSM) to investigate the role of STAT5 signaling in placental dysfunction, inflammation, and fetal immune activation. The project aims to expand scientific understanding of the molecular processes influencing reproductive biology and fetal immune development by leveraging innovative techniques and human...
- The National Institute of Child Health and Human Development (NICHD) awarded a $411,125 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Syracuse University to develop a microfluidic human placenta organoid model. The goal is to generate human trophoblast stem cells (HTSCs) from induced pluripotent stem cells and use them to create a placenta organoid system that can replicate early/mid-gestation placental development. The researchers will study the role of...
- This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $485,925 to the University of Massachusetts Boston to develop novel antioxidant compounds for treating preeclampsia, a life-threatening pregnancy complication. The primary goal is to design and synthesize cationic hydrazone antioxidants that can target mitochondria to reduce oxidative stress, improve...
- This Project Grant award from the Department of Health and Human Services National Institutes of Health National Institute of Child Health and Human Development provides $769,916 to Emergent Biotechnologies LLC for research into a novel therapy for preeclampsia. The funding supports Phase 1 of developing and characterizing a handle region peptide as an innovative treatment for preeclampsia under the Child Health and Human Development Extramural Research program (CFDA 93.865). Phase 1 work will...
- This National Science Foundation (NSF) Biological Sciences project grant, awarded to Worcester Polytechnic Institute (WPI), aims to better understand the role of trophoblast cells and extracellular vesicles (exosomes) in placental function and development. The $502,999 award, effective June 15, 2024 through May 31, 2027, will focus on two key objectives: 1) characterizing how oxygen levels and biochemical factors influence trophoblast invasion of the extracellular matrix, and 2) examining how...
- This $250,000 National Science Foundation Technology, Innovation, and Partnerships Project Grant supports the development of artificial substrates for growing human stem cells suitable for clinical applications at Oakland University from March 2023 to February 2025. The goal is to accelerate the potential benefits of using human pluripotent stem cells and their derivatives for treating and curing diseases by producing a synthetic substrate that supports growth of human pluripotent stem cells...
- This $230,292 Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports research to enhance understanding of how innovative research and development (R&D) effectively translate into commercial products. The study will focus on place-based innovation (PBI) ecosystems, regions where stakeholders collaborate in close geographic proximity, to uncover critical factors that facilitate or hinder successful R&D...
PFI (MCA): MODELING THE TRANSPORT OF PHARMACEUTICAL AGENTS ACROSS THE PLACENTAL BARRIER -THE BROADER IMPACT/COMMERCIAL POTENTIAL OF THIS PARTNERSHIPS FOR INNOVATION ? MID CAREER ADVANCEMENT (PFI-MCA) PROJECT LIES IN AN INNOVATIVE APPROACH AND PLATFORM TECHNOLOGY ? INTEGRATING 3D CELL CULTURE, SENSING, AND IMAGING. THIS SYSTEM WILL FURTHER ENABLE UNDERSTANDING OF PHYSIOLOGICAL PROCESSES AND CAN BE PERSONALIZED FOR EACH EXPECTING MOTHER USING THEIR STEM CELLS, LEADING TO HIGHER ACCURACY IN TESTING FOR THE TRANSPORT RATE OF SPECIFIC COMPOUNDS AND SETTING SAFE EXPOSURE LEVELS. THE SUCCESSFUL COMPLETION OF THIS PROJECT WILL LEAD TO AN ECONOMICAL AND PHYSIOLOGICALLY RELEVANT TOOL THAT ACCOMMODATES TESTING OF A LARGER NUMBER OF COMPOUNDS, FACILITATES HIGH-THROUGHPUT SCREENING AND RAPID DATA COLLECTION, AND THUS ENSURES MARKET POTENTIAL FOR THIS TECHNOLOGY. THE PROPOSED PROJECT PRESENTS A PARADIGM SHIFT FROM THE APPROACH CURRENTLY USED TO STUDY THE TRANSPORT OF PHARMACEUTICAL DRUGS THROUGH THE PLACENTAL BARRIER AND THEIR EFFECTS ON THE DEVELOPING PLACENTA. THIS PLATFORM WILL REPLICATE THE PHYSIOLOGICAL MATRIX MECHANICS, HEMODYNAMICS, AND COMPOUND?S ABILITY TO PERMEATE THROUGH THE PLACENTAL BARRIER, WHICH WILL ENABLE QUANTITATIVE STUDIES TO BE PERFORMED ON A VAST RANGE OF PHARMACEUTICALS TO UNDERSTAND THEIR INTERACTIONS, INCLUDING TRANSPORT THROUGH THE VASCULATURE, AND TRANSLOCATION ACROSS THE PLACENTAL BARRIER TO DIFFUSE INTO THE FETAL BLOOD STREAM. FURTHERMORE, THE SYSTEM CAN ULTIMATELY BE PERSONALIZED FOR EACH EXPECTING MOTHER USING THEIR STEM CELLS. THIS COULD LEAD TO HIGHER ACCURACY IN TESTING THE TRANSPORT RATE OF CERTAIN COMPOUNDS WHILE REDUCING THE COST AND ENABLING REAL-TIME MONITORING AND RAPID DATA COLLECTION. COLLECTIVELY, THE PROPOSED TECHNOLOGY ENABLES THE UNDERSTANDING OF CRITICAL METABOLIC AND INFLAMMATORY PROCESSES IN THE PLACENTA, LAYING THE FOUNDATION FOR ITS POTENTIAL COMMERCIALIZATION IN THE FUTURE. THIS PROJECT IS JOINTLY FUNDED BY THE PARTNERSHIPS FOR INNOVATION PROGRAM AND THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | ($166k) | 3/6/26 | ||
| Not listed | ($7k) | 9/12/25 | ||
| Not listed | $160.0k | 8/22/23 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
028012AS | The Leland Stanford Junior University | Project Grant 2321975 | $31.8k | 12/31/25 |