This National Science Foundation project grant of $746,518 awarded under the Biological Sciences program (CFDA 47.074) supports research into bidirectional transport of lysosome-related organelles during synapse maintenance and plasticity. The University of Florida will investigate how formation and modification of neuronal connections regulates intracellular transport within neurons and between neurons to mediate communication. Specifically, the researchers will study regulation and dynamics of...
The University of Vermont & State Agricultural College (UVM) received a $156,000 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to investigate the mechanism by which the BicaudalD2-Nuclear Pore Protein 358 interaction activates microtubule-based cargo transport. The 2-year project aims to reconstitute the DDBE-K (Dynein, Dynactin, BicD, Egl, Kinesin)...
The National Science Foundation (NSF) awarded a $626,831 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Wisconsin-Milwaukee (UWM) to conduct collaborative research on the molecular mechanisms behind how certain bacteria use light-sensing proteins called phytochromes to regulate essential developmental processes. The project aims to use advanced structural biology techniques like cryo-electron microscopy and time-resolved X-ray crystallography to study...
This $322,978 National Science Foundation (NSF) project grant, awarded under the Biological Sciences (CFDA 47.074) program, aims to enhance the capabilities of the E3-DART protein degradation system for use in plant cell biology research. The key products and services to be delivered include: Developing a ligand-inducible E3-DART system to provide chemically-controlled protein degradation in plant cells. Creating novel recombinant tools to precisely control E3-DART activity. Demonstrating...
This Project Grant award of $335,220.00 was provided by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) Federal Grant Program. The award will fund a collaborative research project between the Kehlenbach and Chook laboratories at The University of Texas Southwestern Medical Center (UT Southwestern) to study the structural and functional characterization of NOSIP, an unusual cargo protein of the nuclear import receptor Transportin. The research aims to investigate...
This $535,743 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at the University of Wisconsin-Madison to investigate the mechanisms controlling cargo transport and localization in developing sensory neurons. The key objectives are to: Determine the mechanisms by which the kinesin light chain 4 (KLC4) protein regulates axon...
This National Science Foundation (NSF) Engineering program (CFDA 47.041) Project Grant award of $342,318 supports research at the University of Wisconsin - Madison to develop a novel theoretical and computational framework for modeling the mechanical deformation and interactions of biomembranes with transport and electrochemical processes. The 3-year research project, starting on Sep 1, 2024, aims to create an open-source computational tool to model key biomembrane phenomena like endocytosis,...
This Project Grant award of $360,000 from the National Science Foundation's Biological Sciences (CFDA 47.074) program aims to investigate the role of neuron-neuron communication, particularly neurotransmitter-based and neuropeptidergic chemical neurotransmission, in the post-mitotic maturation of neurons during postnatal development. The research will utilize the model organism Caenorhabditis elegans and leverage advanced genetics, behavioral assays, microscopy, and genomics tools to examine the...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $373,168 supports collaborative research between the University of Wisconsin-Milwaukee and Northeastern Illinois University to understand the molecular mechanisms behind how myxobacteria use phytochromes to sense light and convert that signal into developmental changes, such as fruiting body formation. The research will utilize cutting-edge techniques including time-resolved X-ray...
This National Science Foundation (NSF) project grant, funded under the Biological Sciences program (CFDA 47.074), supports collaborative research on the mechanisms that regulate co-transmission of multiple neurotransmitters in fruit flies. The $502,569 award to the University of Montana, effective October 1, 2024 through September 30, 2028, will leverage cutting-edge techniques to examine how neurons that co-release glutamate and octopamine are impacted by sexual dimorphism and social isolation....