This $279,376 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) aims to delineate and model the intra- and extra-cellular mechanisms contributing to right ventricular (RV) myocardial stiffening. The primary outcomes will include a multi-scale model that enhances understanding of RV physiology and diastolic dysfunction, as well as open-source computational tools for future cardiovascular research. The research will utilize a combination of experimental and computational approaches, including micro-scale mechanical tests on individual cardiomyocytes and combined cardiomyocyte-extracellular matrix assemblies, as well as machine-learning-based surrogate modeling to link the micro-scale to the organ scale. The project period runs from March 1, 2025 to February 29, 2028 and is being conducted by The Washington University, a prominent private research institution in St. Louis, Missouri.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $279.4k | 12/12/24 |