Project Grant 2244994
- This National Science Foundation (NSF) Project Grant award, under the Engineering program (CFDA 47.041), provides $279,376 to Washington University to conduct research on the mechanisms of right ventricular (RV) stiffening and its impact on cardiac health. The project aims to delineate and model the intra- and extra-cellular mechanisms contributing to RV myocardial stiffening using a combination of experimental and computational approaches. Specifically, the researchers will perform...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $373,596 to the University of Texas at Austin to delineate and model the intra- and extra-cellular mechanisms contributing to right ventricular (RV) myocardial stiffening. The research will utilize a combination of experimental and computational approaches, including micro-scale mechanical tests on individual cardiomyocytes and combined cardiomyocyte-extracellular matrix strip...
- The National Science Foundation awarded a $279,606 Project Grant to the University of California Irvine under the Engineering federal grant program (CFDA 47.041). The grant supports collaborative research to develop multiscale computational models characterizing how heart muscle cells adapt mechanically to changes in load conditions. Through experimental measurement and multi-scale modeling, the university researchers will elucidate the acute functional response and long-term remodeling response...
- This $262,138 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research at the University of Houston to investigate the mechanisms of cardiac fibrosis, a type of scarring in the heart that leads to impaired function. The key objectives are to: 1) determine the role of the endothelial-mesenchymal transition in cardiac fibrosis, and 2) develop a 3D cardiac fibrosis model to study tissue remodeling. The research will leverage a...
- This $117,000 Project Grant award from the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) supports secondary analysis of 3D echocardiographic (echo) images of the right ventricle (RV) to compute 3D surface strain. The goal is to develop enhanced 3D strain analysis techniques that can provide more detailed characterization of RV deformation compared to standard 2D global longitudinal strain (GLS) measures, with the potential to improve...
- This three-year project grant of $409,707 from the National Science Foundation's Engineering program (CFDA 47.041) supports research at Colorado State University to develop adaptive, rapid, and multifunctional soft robots enabled by tunable elastic instabilities. The goal is to create soft robotic devices with reconfigurable shapes and motions. The Engineering program aims to improve engineering research and education quality to foster innovation and economic strength. This award directly...
- This federal Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to understand the biomechanical mechanisms underlying right ventricular (RV) dysfunction and ventricular-arterial uncoupling in pulmonary hypertension. The $642,045 award to the Texas A&M Engineering Experiment Station (Tees) aims to: 1) determine how passive remodeling of the RV free wall competes with...
- This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) will provide $646,451.00 to The Regents of the University of Colorado over a 5-year period from June 1, 2025 to May 31, 2030. The project, titled "CAREER: Defining How Extracellular Matrix Mechanics Regulate Neutrophil Function", will conduct research to understand how a tissue's mechanical properties influence the function of neutrophils, a key immune cell type. The research aims to...
- This $600,000 Project Grant, awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041), aims to provide the first comprehensive mechanobiological characterization of venous valve cells and tissues in the context of chronic venous insufficiency. The principal investigator at North Carolina State University will: 1) Generate and share data on how venous valve endothelial and interstitial cells respond to mechanical forces associated with high blood pressure and tissue...
- The University of California, San Diego was awarded a $551,341 Project Grant from the National Science Foundation's Engineering program (CFDA 47.041) for the period of March 1, 2021 through February 28, 2026. The grant funds research into the mechanical and structural adaptations of blood vessels in pulmonary arterial hypertension. Specifically, the university will examine how blood vessels in the lungs change over time in response to high blood pressure conditions. This work will further the...
Colorado State University will receive $337,430 through June 2030 from the National Science Foundation's Engineering grant program (CFDA 47.041) to conduct collaborative research on changes in right ventricle viscoelasticity under acute stress and chronic pulmonary hypertension. The research aims to improve understanding of the mechanical behavior and pumping function of the right ventricle by analyzing its passive viscoelastic tissue properties experimentally and computationally with disease progression and varied heart rates. The researchers will also study the cellular and extracellular contributions to tissue viscoelasticity through drug treatments and develop a new multiscale model to predict property changes in myofibers and collagen. Educational activities will include engaging K-12 students through STEM kits and outreach events with a focus on mentoring underrepresented groups. The award's results could inform the care of millions of heart failure patients and advance bioengineering education.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $337.4k | 5/30/23 |