Project Grant 2230503
- This $262,138 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research at the University of Houston to investigate the mechanisms of cardiac fibrosis, a type of scarring in the heart that leads to impaired function. The key objectives are to: 1) determine the role of the endothelial-mesenchymal transition in cardiac fibrosis, and 2) develop a 3D cardiac fibrosis model to study tissue remodeling. The research will leverage a...
- This $760,046 federal Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) supports the development of a computationally-efficient multiscale modeling framework that integrates machine learning and artificial intelligence to predict structural and functional changes in the heart due to disease progression. The project aims to build fundamental understanding of heart disease by combining techniques from...
- The National Science Foundation awarded a $450,000 Project Grant to the George Washington University under the Engineering federal grant program (CFDA 47.041) to develop scalable heart-on-a-chip platforms. Over a three-year period from April 2022 through March 2025, the University will create automated systems integrating human heart slice culture components with sensor and actuator arrays. This will enable continuous on-chip multiparametric analysis of human cardiac physiology at the cellular...
- The National Science Foundation (NSF) Engineering program awarded a $695,746 CAREER grant to The Washington University's Office of Sponsored Research Services Division to support research aimed at understanding how to grow more mature heart muscle from induced pluripotent stem cells (iPSCs) in the laboratory. The research project will investigate how combining mechanical loading and changes in energy sources can enhance the electrical maturation of iPSC-derived cardiomyocytes to better predict...
- Florida International University will receive a $697,545 Project Grant award from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation under the Engineering (47.041) federal grant program. The award will support research and education activities focused on harnessing multiscale biophysical cues to engineer adult heart tissue using induced pluripotent stem cells. Specifically, the university will explore how three-dimensional biophysical signals at the...
- This National Science Foundation (NSF) Engineering (CFDA 47.041) program grant, in the amount of $400,000, supports the development of a tissue-like, converged sensing platform for tracking excitation-contraction dynamics in cardiac organoids. The project aims to: Develop a scalable assembly strategy to fabricate an array of three-dimensional sensor structures using planar semiconducting graphene material, designed to detect both electrical and mechanical stimuli. Evaluate the multifunctional...
- This Project Grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation provides $406,551 to Syracuse University under the Engineering (47.041) federal grant program. The funding supports research into probing cellular dynamic mechanobiology using human cardiomyocytes on a stimuli-responsive nano-topographic substrate from Nov 1, 2021 to Oct 31, 2024. Specifically, the awardee will develop new understanding of how human heart muscle cells respond to...
- The National Science Foundation Office of International Science and Engineering awarded a $345,000 Project Grant to the University of California Irvine for research titled "Collaborative Research: Deciphering the Synergistic Interaction between Hemodynamics and Genetics that Form the Heart." The three-year award, issued on June 1, 2021 with a completion date of May 31, 2024, will fund research into the interaction between blood flow and genetics in heart development. This work aligns...
- This National Science Foundation (NSF) Project Grant award, under the Engineering program (CFDA 47.041), provides $279,376 to Washington University to conduct research on the mechanisms of right ventricular (RV) stiffening and its impact on cardiac health. The project aims to delineate and model the intra- and extra-cellular mechanisms contributing to RV myocardial stiffening using a combination of experimental and computational approaches. Specifically, the researchers will perform...
- The University of California, Merced received a $200,000 Project Grant award from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation on May 15, 2022 to support research under the Engineering program (CFDA 47.041). The award will fund research from May 15, 2022 through April 30, 2024 to develop multi-scale models of cell-matrix mechanical interactions during endothelial cell network assembly. The Engineering program seeks to improve quality of life and...
The National Science Foundation awarded a $279,606 Project Grant to the University of California Irvine under the Engineering federal grant program (CFDA 47.041). The grant supports collaborative research to develop multiscale computational models characterizing how heart muscle cells adapt mechanically to changes in load conditions. Through experimental measurement and multi-scale modeling, the university researchers will elucidate the acute functional response and long-term remodeling response of heart muscle cells exposed to complex mechanical loads. In parallel, the university will extend its existing CardioStart outreach program to introduce Minnesota high school students to concepts of cardiac mechano-adaptation. The research aims to advance fundamental understanding of how cardiac tissues respond to mechanical loads, with the goal of informing heart surgery optimization and tissue engineering approaches. No federal subawards were indicated.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $8.0k | 6/12/23 | ||
| Not listed | $271.6k | 12/13/22 |