This National Science Foundation (NSF) Project Grant award for $373,596, provided through the NSF Engineering program (CFDA 47.041), aims to delineate and model the intra- and extra-cellular mechanisms contributing to right ventricular (RV) myocardial stiffening. The primary outcome will be a multi-scale model that enhances understanding of RV physiology and diastolic dysfunction, contributing both mechanobiological insights into RV remodeling and open-source computational tools for future cardiovascular research. The project uses a combination of experimental micro-scale mechanical tests on individual cardiomyocytes and combined cardiomyocyte-extracellular matrix assemblies, as well as computational machine-learning-based surrogate modeling to scale the findings to the organ level. This research is expected to provide valuable insights into a critical determinant of cardiac health and support the development of new diagnostic tools, prognostic markers, and therapeutic strategies for RV-related conditions. The award is held by the University of Texas at Austin and runs from March 1, 2025 to February 29, 2028.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $373.6k | 12/12/24 |