This $725,512 project grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop highly efficient and robust prime editing systems in rice, tomato, and poplar plants. Prime editing is an advanced CRISPR/Cas gene editing technology that enables precise gene modifications, offering significant advantages over conventional CRISPR approaches. The project will optimize prime editor proteins, improve prime editor guide RNA structures and expression, and modify plant DNA repair systems to increase editing efficiency in these three plant species. The goal is to create next-generation prime editing tools to facilitate fundamental plant biology research and enable genetic improvements of important crop traits like yield, quality, disease resistance, and stress tolerance. This collaborative research project will also provide interdisciplinary training for postdoctoral fellows, graduate, and undergraduate students, and conduct outreach activities to engage K-12 students, growers, and the public. The project period is from November 1, 2024 to October 31, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $725.5k | 8/2/24 |