This $500,000 National Science Foundation project grant supports research to advance the biom anufacturing of extracellular vesicles through the integration of human induced pluripotent stem cell technology, genome engineering, and membrane nanofabrication. The primary recipient is Syracuse University, with Rochester Institute of Technology serving as a sub-awardee. Under the Biological Sciences program (CFDA 47.074), the grantees will work to generate a stable human iPSC line with enhanced EV...
The National Science Foundation (NSF) Office of Integrative Activities awarded a $738,400 Project Grant to the Morehouse School of Medicine (MSM) to investigate the synergistic effects of engineered extracellular vesicles (EVs) from stem cells and macrophages on angiogenesis, the formation of new blood vessels. The 4-year project will explore how EVs from different cell types cooperatively regulate normal and pathological angiogenesis, as well as develop novel EV-based therapeutic strategies....
This Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) aims to develop scalable manufacturing processes for engineered extracellular vesicles (EVs) that can serve as targeted drug delivery vehicles. The $2.55M grant to Vanderbilt University, awarded on January 1, 2024, will fund research to harness cellular processes for optimizing EV production, cargo loading, and cellular uptake. The long-term goal is to establish a biomanufacturing platform for...
This National Science Foundation Project Grant of $100,000 supports research into polyelectrolyte multilayered surfaces for use in human mesenchymal stem/stromal cell manufacturing. The goal is to develop a scalable and controllable polymeric coating composed of natural polymers to improve the cell expansion process used in producing therapeutic human mesenchymal stromal cells. The coating is constructed via layer-by-layer assembly of collagen and heparin and has been shown to increase cell...
This Project Grant award, valued at $402,911.00, was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant aims to develop a method for generating a large number of therapeutic nanovesicles (NVs) from mesenchymal stem cells (MSCs) using an extrusion process. These engineered "cell-drones" will be tested for their ability to promote tissue repair in mouse and porcine models of cardiac...
This Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), provides $503,000 to Harvey Mudd College to enhance understanding of extracellular vesicle biogenesis through substrate-associated signals. The research will interrogate factors influencing extracellular vesicle formation and selective cargo packaging in astrocytes. Engineered hydrogel substrates engaging integrins expressed by...
This $546,600 Project Grant awarded by the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) aims to engineer mesenchymal stem cell-derived exosomes (MSC-EXO) for targeted immunomodulation and enhanced bone repair. The University of Maryland Eastern Shore (UMES), a historically black, 1890 land-grant institution, is the primary awardee. The key objectives of this 3-year project are to: 1) generate engineered exosomes (TEX) for reprogramming macrophages, 2) modify...
This Project Grant award for $250,000 was provided by the National Science Foundation (NSF) under the Social, Behavioral, and Economic Sciences (CFDA 47.075) program. The award will support research at the University of Alabama to develop new biomanufacturing methods for producing and characterizing extracellular vesicles (EVs) - small cellular particles that may have applications in drug delivery and regenerative medicine. The project aims to address key challenges in scalable EV production and...
This $349,999 Project Grant, awarded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), aims to create a new biomaterial platform that can precisely control the composition and stiffness of the extracellular matrix (ECM) to investigate how these factors influence airway basal stem cell (BC) self-renewal and differentiation. The interdisciplinary research combines expertise in materials science, stem cell biology, and regenerative medicine to develop an advanced...
This Project Grant award, provided by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to advance gene therapy for neurological disorders by developing a scalable and cost-effective manufacturing process for extracellular vesicle (EV)-based therapeutics. The $304,951 award to Neucore Bio, Inc. will fund research to optimize methods for EV isolation, purification, and cargo loading to enhance therapeutic efficacy, with the goal...