This Project Grant award of $184,388 from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research at the University of California, Irvine to uncover genetic and other factors influencing infection resistance, survival, and tolerance. The project aims to develop bioluminescence imaging tools to enable real-time, longitudinal monitoring of infection progression and host immune responses in fruit flies (Drosophila). This will allow identification of genetic...
This $719,884 National Science Foundation project grant supports research to decipher the regulatory DNA logic of the Drosophila innate immune response. Specifically, the grantee will use allele-specific RNA sequencing to characterize natural variation in the transcriptional response to infection between Drosophila melanogaster lines. This will allow identification of genes with expression variation driven by changes in regulatory DNA. In vivo and in vitro functional genomics assays will...
The National Science Foundation (NSF) awarded a $1,300,000 project grant to the University of Kansas Center for Research Inc. from March 1, 2024 to February 29, 2028 under the NSF Biological Sciences program (CFDA 47.074). The purpose of this grant is to study how immune defense differs among closely related Drosophila species and to determine the genetic basis for these differences. The research aims to improve understanding of how species evolve to fight infections, which has implications...
This National Science Foundation (NSF) Project Grant under the CFDA program "Biological Sciences" (47.074) is awarded to Trustees of Boston University to develop and optimize optogenetic tools for selecting bacterial cells based on dynamic, time-varying traits. The $796,158 award, effective August 1, 2023 through July 31, 2026, supports the researchers in creating light-inducible genetic constructs that trigger antibiotic resistance, enabling the isolation of bacteria exhibiting...
This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $396,000 to the Regents of the University of California at Riverside to study the evolutionary adaptations that allow the fly species Drosophila sechellia to feed exclusively on the toxic noni fruit. The research aims to identify the specific genes responsible for D. sechellia's unique taste preferences and reduced sensitivity to the bitter chemicals in noni fruit compared to...
This $198,724 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research by the University of California, Santa Cruz on the functional genetic basis of the symbiotic relationship between the Wolbachia bacteria and Drosophila fruit flies. The overarching goal is to develop a robust understanding of the evolutionary genetics and functional mechanisms underlying this host-symbiont...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant award, valued at $570,122.00 and effective September 1, 2024, supports a collaborative research effort to investigate innate immune responses in diverse eukaryotic organisms that consume bacteria. The project brings together a cross-disciplinary team of researchers to study innate immunity in sponges, choanoflagellates, and amoebae, which span the evolutionary transition between multicellular animals and their...
This $432,173 Project Grant award was made by the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) to the University of Kansas Center for Research Inc. The award will support research on understanding the genetic drivers of fitness variation in wild fruit fly (Drosophila) populations. Key objectives are to: 1) Identify the genetic processes generating fitness differences among individual flies, including differences in survival, mating success, and gametic...
This Project Grant from the National Science Foundation Division of Emerging Frontiers, under the Biological Sciences federal grant program (CFDA 47.074), provides $502,161 to Appalachian State University to investigate the impacts of evolutionary novelty on generalist species. Specifically, the award will fund research examining toxin tolerance in Drosophila tripunctata fruit flies that use diverse mushrooms and fruits as hosts. The university will test hypotheses about how toxin tolerance...
This $238,681 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) funds research into the genetic architecture of exploration behavior in Drosophila at the University of Houston-Downtown. The researchers will use novel arena exploration assays and integrated genetic approaches to identify genes and neurons responsible for neophilia, or attraction to novel stimuli. Specifically, they will determine dopamine signaling requirements for exploratory...
This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences (CFDA 47.074) program, supports collaborative research to uncover the genetic and stochastic factors that influence infection resistance, survival, and tolerance in fruit flies (Drosophila). The $584,772 award to Trustees of Boston University aims to develop new bioluminescence imaging tools for real-time, longitudinal monitoring of infection progression and host immune responses in individual animals. This approach will help identify novel immune genes and the roles of fluctuations in microbial growth and host response on infection outcomes. The research, spanning August 2025 to July 2028, has two key goals: 1) uncover the genetic drivers of infection resistance, tolerance, and survival, and 2) uncover the stochastic contributions to infection outcome. The project also provides training for students and postdoctoral researchers and creates educational materials to inspire the next generation of American scientists.