This National Science Foundation project grant of $1,261,723 will fund research into the predatory behavior of the amoeba Dictyostelium discoideum through January 2027. Under the Biological Sciences program (CFDA 47.074), the award made to Washington University will support investigation into how this microbe evolves to be a generalist or specialist predator of bacteria. The researchers will study D. discoideum's responses to a panel of 15 diverse bacterial species through experiments on...
This two-year Project Grant from the National Science Foundation's Division of Biological Infrastructure, under the Biological Sciences program (CFDA 47.074), provides $138,000 to explore the biophysical mechanisms and genetics influencing dendritic cell migration. The fellow will determine how dendritic cells push, pull, and squeeze through tissues using tunable biomaterials and confocal microscopy. They will investigate how mechanical properties of tissues impact dendritic cell movement and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, is funding a research project titled "Investigating the Role of Signaling Feedback in Directed Cell Migration." The $147,656 award, with a project period from December 2024 to September 2027, will support investigations into the mechanisms by which cells regulate signaling pathways to control navigation during cell...
This National Science Foundation (NSF) Biological Sciences program project grant, awarded to Oregon Health & Science University (OHSU), aims to uncover the underlying biophysical mechanisms of directed cell migration. The $1,049,497 grant, with a period of performance from January 2024 to December 2027, will examine how actin cytoskeletal networks and adhesion receptors interact as interdependent subsystems to facilitate matrix-guided cell migration, which is crucial for tissue formation and...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $1,199,995 Project Grant to The Washington University in St. Louis to characterize the genetic and epigenetic determinants of the transition from unicellular to multicellular states in the slime mold Dictyostelium discoideum. The project, funded through the Biological Sciences CFDA Program (47.074), leverages this organism's ability to regularly shift between unicellular and multicellular forms to...
This $1,269,993 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to understand the molecular basis of how plant cells establish the division plane during cell division. The project aims to dissect the function of cytoskeletal motor assemblies at the cortical division site and determine how they connect to molecules in the phragmoplast, the structure that forms the new cell wall during cytokinesis. Researchers at...
This Project Grant award, totaling $805,374.00, is funded by the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program. The primary focus of this 5-year research project, awarded to Rutgers, The State University, is to uncover the fundamental principles governing how cells sense and respond to mechanical forces at their surface. By investigating mechanosensitive membrane proteins, such as Piezo channels, the project aims to establish a thermodynamic...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049) provides $380,000 to Northeastern University to develop a new generation of computational models for studying eukaryotic cell motility. The research aims to better understand how cells move through complex tissues, which is critical for both healthy developmental processes and the spread of cancer. The project will involve a collaborative effort between...
This federal Project Grant award, provided by the National Science Foundation (NSF) through its Biological Sciences program (CFDA 47.074), supports fundamental research on the periplasmic chaperone network in bacterial cell surface formation. The $1,320,970 award to The Johns Hopkins University will investigate the physical principles and mechanisms governing this essential cellular process in bacteria, one of the most abundant forms of life on Earth. The multi-scale research approach will...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding research at Yale University to study variations in chemotactic strategies across bacterial species. The $645,905 award, effective May 1, 2025 through March 31, 2030, will support two main research directions: 1) using single-cell fluorescence to characterize chemotactic signal processing in Vibrio cholerae, and 2) examining the role...