Project Grant 2421800

Award Date 9/1/24
Completion Date 8/31/28
Dollars Obligated $1.2M
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Reno, NV 89557, USA
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This $297,957 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program aims to investigate the role of gene copy number variation in determining detoxification capacity, individual fitness, and population dynamics for a vertebrate herbivore, the woodrat. The project will combine field observations, genome sequencing, chemical analyses, and computer modeling to understand how structural genetic variation influences the ability of woodrats to...
This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) totaling $468,344 is supporting research to explore the phenotypic consequences of copy number variation in ribosomal RNA (rRNA) genes. The project, led by The Research Foundation For The State University Of New York, will use the model organism Caenorhabditis elegans to investigate the lower bounds of rRNA copy number required for healthy development and identify impacts on...
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This Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) program provides $1,239,776 to the University of Nevada, Reno (UNR) to conduct collaborative research on the role of gene copy number variation in determining detoxification capacity, individual fitness, and population dynamics of a vertebrate herbivore.

The key objectives of this 4-year research project are to: 1) identify individual copy number variation in detoxification genes, 2) quantify the capacity of different copy number variants to detoxify phytochemicals, and 3) predict how structural variation in detoxification gene families interacts with environmental stressors to impact individual fitness and population responses to environmental change. The research will focus on a hybrid zone between two woodrat species, leveraging high rates of admixture to generate individuals with novel structural variants. Findings from this study are expected to provide unprecedented insight into the functional significance of copy number variation and advance understanding of how genetic mechanisms facilitate or hinder population persistence in the face of environmental challenges.

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