The National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) has awarded a $468,344 Project Grant to The Research Foundation for the State University of New York (RF SUNY) at Brockport for the project "BRC-BIO: EXPLORING THE PHENOTYPIC CONSEQUENCES OF COPY NUMBER VARIATION OF THE RIBOSOMAL RNA GENES." This 3-year project, running from Mar 2025 to Feb 2028, will investigate genetic variations in the number of copies of ribosomal RNA genes and their impact on development, tumor formation, lifespan, and cellular function using the model organism Caenorhabditis elegans. The research aims to advance the understanding of the relationship between genotype and phenotype, as well as provide undergraduate research training opportunities at SUNY Brockport. The project will leverage CRISPR-Cas9 genetic engineering to manipulate ribosomal RNA gene copy number and assess the resulting phenotypic consequences. Additionally, the project will explore the small RNA landscape in the context of these copy number variations.
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