Project Grant 2417808

Award Date 9/1/24
Completion Date 8/31/26
Dollars Obligated $250K
Awarding Federal Agency
Division of Chemistry
Federal Grant Program
47.049
Assistance Type
Project Grant
Place of Performance
Buies Creek, NC 27506, USA
Similar Awards
This Project Grant award of $510,759 from the National Science Foundation (NSF) Division of Chemistry supports a research collaboration led by Professors Andrew Mitchell of Illinois State University and Dean Tantillo of UC-Davis. The goal is to develop new chemical reactions with connections to biology, medicine, physics, materials, and environmental sustainability. Key products include: Advancing oxidopyrylium-based [5+2] cycloaddition reactions to construct important heterocyclic small...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (MPS) Federal Grant Program provides $770,000 in funding to the Regents of the University of California at Riverside to develop new chemical reactions and catalysts that can streamline the synthesis of molecules relevant to the pharmaceutical and agrochemical industries. The grant supports research led by Dr. Kevin Kou to explore the use of rhodium and cobalt catalysts to convert abundant...
The National Science Foundation (NSF) awarded a $513,894 Project Grant under its Mathematical and Physical Sciences program (CFDA 47.049) to Tufts University. This 3-year grant, effective July 1, 2023, supports Professor Clay S. Bennett's research to develop new methods for synthesizing deoxy sugars - an important component of many biologically active natural products. The project aims to expand upon approaches that activate sugar hemiacetals as glycosyl sulfonates or tert-butyldimethylsilyl...
This $369,297 Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program supports research at San Francisco State University to develop a synthetic transhydrogenation module to enhance biosynthesis of valuable chemicals. The key objectives are to: 1) elucidate the structural mechanisms underlying autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism, 2) leverage this understanding to engineer...
Under this $566,966 Project Grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049), Professor Tadhg Begley of Texas A&M University will study the enzymes involved in menaquinone biosynthesis via the futalosine pathway. The research aims to complete mechanistic characterization of the remaining four enzymes in the futalosine-dependent menaquinone pathway, which converts chorismate to 1,4-dihydroxy-6-naphthoic acid. Studies will reconstitute...
This Project Grant award from the National Science Foundation (NSF) Division of Chemistry provides $160,244 to Temple University to support the research of Professor Christopher M. Beaudry in developing new chemical reactions that enable more efficient syntheses of pharmaceutical and fine chemical products. The research will focus on transforming aromatic ring compounds, such as benzenes, pyrones, and pyridines, into other cyclic and polycyclic molecules through pericyclic reactions. This...
This $447,000 Project Grant from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), will support research at Haverford College from December 2022 through February 2026. The research team, led by Dr. Louise Charkoudian, will investigate type II polyketide biosynthetic enzyme assemblies across bacterial species to leverage their capabilities for sustainable chemical production. Undergraduate students will gain research...
This $575,000 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research at Emory University to develop new synthetic methods and enabling strategies for the production of Ribosomally Synthesized Post-Translationally Modified Peptides (RiPPs). The goal is to create a universal catalytic platform to enable the synthesis of diverse RiPP natural products, which have shown promise as drug candidates but face...
Professor Daniel Romo of Baylor University will utilize $1,070,000 in funding from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) over a three year period from July 2022 to June 2025. The project aims to advance the development of novel organocatalytic cascade and domino reaction processes for rapidly constructing structurally complex molecules relevant to bioactive natural products and pharmaceutical synthesis. Specifically, the funding will...
This $250,000 Project Grant award was made by the National Science Foundation's (NSF) Directorate for Mathematical and Physical Sciences, under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program, to the University of North Carolina at Greensboro (UNC-G). The grant will fund a research project led by Professor Chekan and his students to engineer and evolve copper-dependent enzymes that can be used as biocatalysts for targeted peptide cyclization. This work aims to...

This Project Grant award, provided by the National Science Foundation's Mathematical and Physical Sciences (MPS) Directorate, will support research by Professor Reynolds and his students at Campbell University to study the application of thiamine diphosphate-dependent enzymes for sustainable chemical synthesis. The $250,000 award, with a period of performance from September 1, 2024 to August 31, 2026, will enable the exploration of these enzymes for the stereoselective formation of α-substituted ketones, which are important precursors to more complex, bioactive compounds. The research aims to expand the scope of reactions available to thiamine-dependent enzymes, making them more broadly useful for chemical synthesis. This work also promotes the retention of diverse talent in STEM fields through research and mentoring opportunities for underrepresented students.

Generated 4/8/25, 3:02 AM