The University of North Carolina at Chapel Hill will receive $495,000 from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) to support research into designing artificial enzymes from June 2022 to May 2025. Dr. Albert Bowers and his team will develop a generalizable strategy for separating substrate binding and catalysis functions into distinct domains for peptide-based enzymes. They will use computational protein design with Rosetta to create...
The National Science Foundation, through its Division of Chemistry and the Mathematical and Physical Sciences program (CFDA 47.049), awarded a $577,690 Project Grant to the University of North Carolina at Chapel Hill from July 1, 2023 through June 30, 2027. The grant supports research to characterize the biosynthetic pathways of dehydroamino acids in nonribosomal peptides, which are biologically and industrially important natural products. The research aims to understand the molecular details of...
The University of North Carolina at Chapel Hill received a $300,081 Project Grant award from the National Science Foundation Division of Chemistry on August 15, 2021 to support research titled "Collaborative Research: Probing Coordination Specificity of Metalloprotein Domains with Peptide-Polymer Amphiphile Self Assembly." The award has a completion date of July 31, 2024. The research is being conducted under the Mathematical and Physical Sciences program (CFDA #47.049) to advance...
This $575,000 federal Project Grant, awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program, supports the University of North Carolina at Chapel Hill in developing new sustainable nickel-catalyzed coupling methods for the stereoselective synthesis of complex organic molecules. The 3-year project, led by Professor Simon Meek, focuses on creating efficient, site- and stereo-controlled multicomponent reactions using simple carbonyl-type...
The University of North Carolina at Chapel Hill (UNC-CH), through its Office of Sponsored Research, received a $529,988 Project Grant from the National Science Foundation's (NSF) Mathematical and Physical Sciences (MPS) Federal Grant Program (CFDA 47.049). This 3-year grant, effective July 1, 2024, supports the development of new biomimetic model systems that imitate the complex behavior of proteins. Professor Marcey Waters at UNC-CH will lead research to determine the molecular features...
This $468,099 Project Grant award from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), supports efforts by Dr. Yao Lin at the University of Connecticut to develop new strategies for synthesizing synthetic polypeptides under metal-free, auto-catalyzed conditions. The project aims to refine a "helix-guided polymerization" process to enable more efficient and controlled synthesis of protein-like polymers,...
This $309,414 Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry, under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program, supports research at the University of North Carolina at Greensboro (UNC-G) to develop a new class of photocatalysts that can transform cheap, unreactive raw materials into value-added chemicals. The goal is to control the photochemical process and reaction selectivity by modulating the energy of the light...
This Project Grant award for $450,000 was provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The funding supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University to investigate a group of four enzymes that utilize a single iron atom and molecular oxygen to catalyze diverse chemical reactions. The goal is to elucidate the...
This Project Grant award of $900,000.00 from the National Science Foundation's (NSF) Division of Chemistry, under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), supports research by Professors Houk and Tang of the University of California, Los Angeles (UCLA) to study the development of a new class of enzymes called "pericyclases." The researchers aim to characterize the mechanisms by which these enzymes catalyze natural product biosynthetic reactions,...
The National Science Foundation awarded a $249,988 Project Grant to the University of North Carolina at Greensboro under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new photocatalysts for green oxidation processes. Professor Shabnam Hematian and her research team will study catalytic processes using light and oxygen to generate value-added chemicals from hydrocarbons. Specifically, the team will develop oxo-bridged heterobinuclear systems containing different metal...