This $184,017 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) supports a collaborative research project led by Professors Pablo Sobrado of Missouri University of Science and Technology and John Tanner of the University of Missouri Columbia. The project explores the mechanisms, functional diversity, and conformational dynamics of flavin-dependent monooxygenase enzymes found in plants. The research aims to establish...
This $597,945 federal Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports research by Tobias W. Giessen at the University of Michigan, Ann Arbor to investigate the structure and function of peptide-modifying enzyme filaments found in bacteria and archaea. The proposed work will generate new insights into the self-assembly and catalytic activity of these filamentous enzymes, which...
This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) provides $369,297 to San Francisco State University (SFSU) to develop a synthetic transhydrogenation module to enhance the production of valuable chemicals using engineered organisms. The key objectives are to: Elucidate the structural mechanisms underlying the autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism and impacts...
This National Science Foundation (NSF) Division of Chemistry award, under the Mathematical and Physical Sciences grant program (CFDA 47.049), provides $133,259 to Professors Pablo Sobrado of Missouri University of Science and Technology and John Tanner of the University of Missouri Columbia to study enzymes from plants that synthesize specialized molecules for defense and flavor. The 3-year project (1/1/2025 - 12/31/2027) will explore the mechanisms, functional diversity, and conformational...
This Project Grant award for $450,000 was provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The funding supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University to investigate a group of four enzymes that utilize a single iron atom and molecular oxygen to catalyze diverse chemical reactions. The goal is to elucidate the...
This three-year, $525,000 Project Grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports coordinated mechanistic approaches to desulfonation in two-component FMN monooxygenases. East Carolina University will deliver structural investigations of alkane sulfonate monooxygenase systems through X-ray crystallography and analysis, with the University of Massachusetts Boston performing the crystallography work. Quantum mechanical calculations...
The National Science Foundation Division of Chemistry awarded a three-year Project Grant of $495,000 to the University of Texas at San Antonio to support research investigating protein-derived cofactors containing a cysteine-tyrosine crosslink. This work falls under the Mathematical and Physical Sciences program (CFDA 47.049), which aims to advance scientific knowledge and understanding of major problems. Specifically, the award will fund graduate and undergraduate students to elucidate the...
This three-year project grant from the National Science Foundation Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), provides $462,000 to Virginia Polytechnic Institute and State University from July 2021 through June 2024. The grant supports mechanistic investigation of radical SAM methylases involved in tetrahydromethanopterin biosynthesis. A sub-award of $100,000 is also provided to Auburn University to support related research into the mechanistic...
This Project Grant award, funded by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), supports research at the University of Texas at Austin to study how the secondary coordination sphere (SCS) affects the activity of copper enzymes. The $594,870 award from August 1, 2024 to July 31, 2027 employs a novel biosynthetic approach to modulate copper enzyme activity, with potential applications in areas like...
This $447,000 Project Grant from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), will support research at Haverford College from December 2022 through February 2026. The research team, led by Dr. Louise Charkoudian, will investigate type II polyketide biosynthetic enzyme assemblies across bacterial species to leverage their capabilities for sustainable chemical production. Undergraduate students will gain research...